ArticleScientific reports2022
Association of bleb formation with peri-aneurysmal contact in unruptured intracranial aneurysms.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 10 citations in OpenAlex.
- Dome-remnant dissociation after coil embolization of a basilar tip aneurysm: serial MR cisternography, silent MRA, and computational fluid dynamics findings suggest early hemodynamic redistribution. Illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Hemodynamic remnant drift after coil embolization: longitudinal silent MRA and computational fluid dynamics analysis of a migratory neck remnant. Illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Article
- Assessment of morphology and hemodynamics in a surgically clipped neck of a cerebral aneurysm: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Evaluation of the shrinkage process of a neck remnant after stent-coil treatment of a cerebral aneurysm using silent magnetic resonance angiography and computational fluid dynamics analysis: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Hemodynamic analysis of a thrombosed bleb in an unruptured cerebral aneurysm.Surgical neurology international · 2024Article
- Dual Microscope Indocyanine Green Video Angiography and Endoscopic Review to Treat Intracranial Aneurysm: A Review of the Literature Regarding a Case.Asian journal of neurosurgery · 2023Review
- Understanding intracranial aneurysm sounds via high-fidelity fluid-structure-interaction modelling.Communications medicine · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of bleb formation in unruptured intracranial aneurysms (UIAs) remains unclear. This study aimed to investigate the association between peri-aneurysmal contact (PAC) and bleb formation. Forty-five aneurysms were classified depending on the presence of blebs and PAC using computed tomographic angiography and magnetic resonance imaging. Aneurysmal hemodynamics were assessed using computational fluid dynamics. The independent variables associated with bleb formation were statistically assessed. Fourteen aneurysms (31.1%) had blebs, all of which were located at the site of PAC (group A). Thirty-one aneurysms (68.9%) had no bleb, of which 13 had a PAC (group B) and 18 had no PAC (group C). PAC was the only independent variable associated with bleb formation (p < 0.05). Aneurysmal volumes were significantly higher in group A, followed by groups B and C in series. Aneurysmal wall shear stress (WSS) tended to be lowest in group A, followed by groups B and C in series. The maximum WSS at the blebs was only 17% of the maximum WSS at the aneurysmal domes. This study demonstrated that bleb formation in UIAs was associated with the establishment of PAC during their growth, which may have more detrimental effects on bleb formation than hemodynamics.
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