Evidence map›Paper›PMID 35414007›Full record

ArticleJournal of neuroinflammation2022

Synaptic loss and progression in mice infected with Angiostrongylus cantonensis in the early stage.

Kai-Yuan Jhan, Pi-Kai Chang, Chien-Ju Cheng, Shih-Ming Jung, Lian-Chen Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kai-Yuan Jhan *Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.
Pi-Kai Chang *Department of Parasitology, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.
Chien-Ju ChengDepartment of Parasitology, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.
Shih-Ming JungDepartment of Pathology, Chang-Gung Memorial Hospital, Chang-Gung Children Hospital at Linkou and Chang-Gung University, Taoyuan, 333, Taiwan.
Lian-Chen WangGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan. wanglc@mail.cgu.edu.tw.ORCID http://orcid.org/0000-0002-6862-2215
Chang Gung University · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPD1H0343Chang Gung Memorial Hospital, Linkou CMRPD1H0443Ministry of Science and Technology, Taiwan MOST109-2320-B-182-032-MY3
6 · The paper itself

Abstract

backgroundAngiostrongylus cantonensis is also known as rat lungworm. Infection with this parasite is a zoonosis that can cause eosinophilic meningitis and/or eosinophilic meningoencephalitis in humans and may lead to fatal outcomes in severe cases. In this study, we explored the mechanisms of the impairments in the cognitive functions of mice infected with A. cantonensis.

methodsIn infected mice with different infective intensities at different timepoint postinfection, loss and recovery of cognitive functions such as learning and memory abilities were determined. Neuronal death and damage to synaptic structures were analyzed by Western blotting and IHC in infected mice with different infection intensities at different timepoint postinfection.

resultsThe results of behavioral tests, pathological examinations, and Golgi staining showed that nerve damage caused by infection in mice occurred earlier than pathological changes of the brain. BDNF was expressed on 14 day post-infection. Cleaved caspase-3 increased significantly in the late stage of infection. However, IHC on NeuN indicated that no significant changes in the number of neurons were found between the infected and uninfected groups.

conclusionsThe synaptic loss caused by the infection of A. cantonensis provides a possible explanation for the impairment of cognitive functions in mice. The loss of cognitive functions may occur before severe immunological and pathological changes in the infected host.

Indexed as

Angiostrongylus cantonensisMeningitisStrongylida InfectionsAnimalsBrainDisease Models, AnimalMiceRatsAngiostrongylus cantonensisBehavioral testCognitive functionGolgi stainingNeuronal deathPathological changesSynaptic loss

Identifiers

PMID35414007
PMCPMC9006624
OpenAlexW4223473646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.