Evidence map›Paper›PMID 35413856›Full record

ArticleBMC neurology2022

Ipsilesional arm training in severe stroke to improve functional independence (IPSI): phase II protocol.

Candice Maenza, Robert L Sainburg, Rini Varghese, Brooke Dexheimer, Marika Demers, Lauri Bishop, Shanie A L Jayasinghe, David A Wagstaff, Carolee Winstein, IPSI Investigative Team

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03634397 (Predicting Ipsilesional Motor Deficits in Stroke With Dynamic Dominance Model), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03634397 nacompletednot on this map

Predicting Ipsilesional Motor Deficits in Stroke With Dynamic Dominance Model

TypeinterventionalSponsorRobert L. SainburgRan2019 to 2024Enrolled58ConditionsStrokeArmsLess-Impaired Arm Training, Contralesional Arm Comparison
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Candice MaenzaDepartment of Neurology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. CChopick@PennStateHealth.PSU.edu.ORCID http://orcid.org/0000-0002-4638-2759
Robert L SainburgDepartment of Neurology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Rini VargheseDivision of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
Brooke DexheimerDepartment of Kinesiology, Pennsylvania State University, 27 Rec Hall, University Park, PA, 16802, USA.
Marika DemersDivision of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
Lauri BishopDivision of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
Shanie A L JayasingheDepartment of Neurology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
David A WagstaffDepartment of Human Development and Family Studies, Pennsylvania State University, 102 HHD Building, University Park, PA, 16802, USA.
Carolee WinsteinDivision of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
IPSI Investigative Team
Pennsylvania State University · USUniversity of Southern California · US

Funding

Predicting Ipsilesional Motor Deficits in Stroke with Dynamic Dominance ModelR01HD059783 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SAINBURG, ROBERT L, WINSTEIN, CAROLEE J · 2010 to 2023
$5.3M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 2 R01 HD059783-06A1NICHD NIH HHS R01 HD059783
6 · The paper itself

Abstract

backgroundWe previously characterized hemisphere-specific motor control deficits in the ipsilesional, less-impaired arm of unilaterally lesioned stroke survivors. Our preliminary data indicate these deficits are substantial and functionally limiting in patients with severe paresis.

methodsWe have designed an intervention ("IPSI") to remediate the hemisphere-specific deficits in the ipsilesional arm, using a virtual-reality platform, followed by manipulation training with a variety of real objects, designed to facilitate generalization and transfer to functional behaviors encountered in the natural environment. This is a 2-site (primary site - Penn State College of Medicine, secondary site - University of Southern California), two-group randomized intervention with an experimental group, which receives unilateral training of the ipsilesional arm throughout 3 one-hour sessions per week for 5 weeks, through our Virtual Reality and Manipulation Training (VRMT) protocol. Our control group receives a conventional intervention on the contralesional arm, 3 one-hour sessions per week for 5 weeks, guided by recently released practice guidelines for upper limb rehabilitation in adult stroke. The study aims to include a total of 120 stroke survivors (60 per group) whose stroke was in the territory of the middle cerebral artery (MCA) resulting in severe upper-extremity motor impairments. Outcome measures (Primary: Jebsen-Taylor Hand Function Test, Fugl-Meyer Assessment, Abilhand, Barthel Index) are assessed at five evaluation points: Baseline 1, Baseline 2, immediate post-intervention (primary endpoint), and 3-weeks (short-term retention) and 6-months post-intervention (long-term retention). We hypothesize that both groups will improve performance of the targeted arm, but that the ipsilesional arm remediation group will show greater improvements in functional independence. DISCUSSION: The results of this study are expected to inform upper limb evaluation and treatment to consider ipsilesional arm function, as part of a comprehensive physical rehabilitation strategy that includes evaluation and remediation of both arms.

trial registrationThis study is registered with ClinicalTrials.gov (Registration ID: NCT03634397 ; date of registration: 08/16/2018).

Indexed as

StrokeStroke RehabilitationAdultClinical Trials, Phase II as TopicFunctional StatusHumansParesisRecovery of FunctionTreatment OutcomeUpper ExtremityArm trainingIpsilateral deficitsIpsilesional deficitsLess-impaired armStroke motor deficitsStroke rehabilitationStroke remediationVirtual reality training

Identifiers

PMID35413856
PMCPMC9002228
OpenAlexW4223438752

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.