ArticleDevelopmental cognitive neuroscience2022
Structure-function coupling within the reward network in preschool children predicts executive functioning in later childhood.
Article in Developmental cognitive neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 25 citations in OpenAlex.
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Sex-specific neurodevelopmental pathways to depressive symptoms.Molecular psychiatry · 2026Article
- Developing a multi-modal neuroimaging-based BrainAge model across childhood.bioRxiv : the preprint server for biology · 2026Article
- Individualized identification value of stress-related network structural-functional properties and HPA axis reactivity for subthreshold depression.Translational psychiatry · 2024Article
- Elevated Activity in Left Homologous Music Circuits Is Inhibitory for Music Perception but Mediated by Structure-Function Coupling.CNS neuroscience & therapeutics · 2024Article
- Spatial and temporal pattern of structure-function coupling of human brain connectome with development.eLife · 2024Article
- Spatial and temporal pattern of structure-function coupling of human brain connectome with development.bioRxiv : the preprint server for biology · 2024Article
- Associations Between Executive Functioning, Behavioral Functioning, and Adaptive Functioning Difficulties in Wiedemann-Steiner Syndrome.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Heritability and genetic contribution analysis of structural-functional coupling in human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Aberrant dynamic Functional-Structural connectivity coupling of Large-scale brain networks in poststroke motor dysfunction.NeuroImage. Clinical · 2023Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early differences in reward behavior have been linked to executive functioning development. The nucleus accumbens (NAc) and orbitofrontal cortex (OFC) are activated by reward-related tasks and identified as key nodes of the brain circuit that underlie reward processing. We aimed to investigate the relation between NAc-OFC structural and functional connectivity in preschool children, as well as associations with future reward sensitivity and executive function. We showed that NAc-OFC structural and functional connectivity were not significantly associated in preschool children, but both independently predicted sensitivity to reward in males in a left-lateralized manner. Moreover, significant NAc-OFC structure-function coupling was only found in individuals who performed poorly on executive function tasks in later childhood, but not in the middle- and high-performing groups. As structure-function coupling is proposed to measure functional specialization, this finding suggests premature functional specialization within the reward network, which may impede dynamic communication with other regions, affects executive function development. Our study also highlights the utility of multimodal imaging data integration when studying the effects of reward network functional flexibility in the preschool age, a critical period in brain and executive function development.
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