SynthesisThe American journal of emergency medicine2022
The association between pregnancy and COVID-19: A systematic review and meta-analysis.
Synthesis in The American journal of emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The impact of COVID-19 infections on pregnancy outcomes in women.BMC pregnancy and childbirth · 2024Pooled it
- Infectious comorbidities in pregnant patients with rheumatic diseases.Rheumatology international · 2026Review
- Severe COVID-19 in Pregnant Versus Nonpregnant Women: Intensive Care Unit Outcomes and Perinatal Risks.Journal of medical virology · 2026Article
- Comparison of SARS-CoV-2 total and neutralizing antibody transfer to neonates from vaccinated mothers vs. mothers infected during pregnancy: an observational study.BMC pregnancy and childbirth · 2026Observational
- Article
- Article
- Pregnant hospitalized COVID-19 patients: disease, delivery, maternal and fetal outcomes.BMC pregnancy and childbirth · 2025Observational
- Article
- Effect of maternal COVID-19 vaccination on mandibular molars development in albino rats offspring.Scientific reports · 2025Article
- The impact of COVID-19-related anxiety on obstetric complications and mental health in quarantined pregnant women.BMC infectious diseases · 2025Article
- Article
- Preterm Birth and SARS-CoV-2: Does a Correlation Exist?Biomedicines · 2025Review
- Mortality, intensive care unit admission, and ventilatory support in pregnant and nonpregnant women with COVID-19 in Brazil: a paired observational study.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025Observational
- Validation of the APACHE‑II scoring system in critically ill patients diagnosed with COVID‑19 and admitted at a regional‑level hospital intensive care unit: A retrospective study.The Southern African journal of critical care : the official journal of the Critical Care Society · 2025Article
- COVID-19 in pregnancy: Perinatal outcomes and complications.World journal of virology · 2024Article
- Association of maternal infection of SARS-CoV-2 and neonatal susceptibility: A retrospective cohort study.Vaccine: X · 2024Article
- Add-on hemoperfusion in SARS-CoV-2-infected pregnant patients: a case series.Journal of medical case reports · 2024Article
- COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales.NPJ vaccines · 2024Article
- Successful use of tocilizumab and casirivimab/imdevimab in a twin pregnancy with critical COVID-19 - A case report.Heliyon · 2024Article
- Community antibiotic prescribing in patients with COVID-19 across three pandemic waves: a population-based study in Scotland, UK.BMJ open · 2024Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to compare and determine whether there were any differences in clinical outcomes between pregnant and non-pregnant women who had been infected with COVID-19.
methodsA literature search was performed in 9 databases on November 20, 2021. The relative risk (RR) with 95% confidence interval (95% CI) was used to estimate the effect of pregnancy on COVID-19 outcomes. The I square value was used to assess heterogeneity, and the random or the fixed-effects model were adopted. Sensitivity and publication bias analyses were performed.
resultsThis study included 8 published studies with 859,278 COVID-19 female patients. The incidences of fever and cough among pregnant women with COVID-19 were 19.07% and 28.79%, respectively. Pregnancy was associated with significantly increased risks of intensive care unit (ICU) admission (RR = 2.23, 95% CI = 1.58-3.16) and ventilation (RR = 2.13, 95% CI = 1.06-4.28), but was not associated with a statistically significant increase in mortality.
conclusionsOur results suggest that pregnant women with COVID-19 have a significantly higher probability of being hospitalized to the ICU and ventilation than non-pregnant women with COVID-19. To avoid these adverse outcomes, pregnant women should take precautions (for example, reduce going out, maintain social distance, and wear a mask) to avoid COVID-19 infection. Finally, additional research into the fetal outcomes is required to better investigate the impact of COVID-19 on pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.