Evidence map›Paper›PMID 35413499›Full record

ArticleTranslational oncology2022

Novel IL-15 dendritic cells have a potent immunomodulatory effect in immunotherapy of multiple myeloma.

Tan-Huy Chu, Manh-Cuong Vo, Thangaraj Jaya Lakshmi, Seo-Yeon Ahn, Mihee Kim, Ga-Young Song, Deok-Hwan Yang, Jae-Sook Ahn, Hyeoung-Joon Kim, Sung-Hoon Jung and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Tan-Huy ChuBioMedical Sciences Graduate Program, Chonnam National University, South Korea; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Manh-Cuong VoInstitute of Research and Development, Duy Tan University, Danang, Vietnam; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Thangaraj Jaya LakshmiDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Seo-Yeon AhnDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Mihee KimDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Ga-Young SongDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Deok-Hwan YangDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Jae-Sook AhnDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Hyeoung-Joon KimDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea.
Sung-Hoon JungDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea. Electronic address: shglory@hanmail.net.
Je-Jung LeeBioMedical Sciences Graduate Program, Chonnam National University, South Korea; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, South Korea. Electronic address: drjejung@chonnam.ac.kr.
Chonnam National University Hwasun Hospital · KRChonnam National University · KRChonnam National University Hospital · KRDuy Tan University · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are the most potent antigen-presenting cells, and have thus been used in clinical cancer vaccines. However, the effects of DC vaccines are still limited, leading researchers to explore novel ways to make them effective. In this study, we investigated whether human monocyte-derived DCs generated via the addition of interleukin 15 (IL-15) had a higher capacity to induce antigen-specific T cells compared to conventional DCs. We isolated CD14

Indexed as

cytokine induced killer cellsImmunologymultiple myelomanatural killer cellsT cells

Identifiers

PMID35413499
PMCPMC9006865
OpenAlexW4223618554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.