Evidence map›Paper›PMID 35413222›Full record

ArticleCanadian journal of physiology and pharmacology2022

Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice.

Elizabeth Saurage, Parker R Davis, Rachel Meek, David M Pollock, Malgorzata Kasztan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of physiology and pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Endothelin receptor antagonism in sickle cell disease: Is the time now?Canadian journal of physiology and pharmacology · 2026
    Review
  2. Iron TAMs: The fallen protectors.The Journal of experimental medicine · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elizabeth SaurageCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Parker R DavisCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Rachel MeekCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
David M PollockCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Malgorzata KasztanCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Pediatric Nephrology of Alabama · USUniversity of Alabama at Birmingham · US

Funding

The Role of Endothelin-1 in Tubular Injury in Sickle Cell DiseaseR00HL144817 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KASZTAN, MALGORZATA · 2021 to 2023
$747k
The role of endothelin-1 in tubular injury in sickle cell diseaseK99HL144817 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KASZTAN, MALGORZATA · 2019 to 2020
$306k
NHLBI NIH HHS K99 HL144817NHLBI NIH HHS R00 HL144817
6 · The paper itself

Abstract

Progressive iron accumulation and renal impairment are prominent in both patients and mouse models of sickle cell disease (SCD). Endothelin A receptor (ET

Indexed as

Anemia, Sickle CellIron OverloadAnimalsEndothelin-1Endothelin A Receptor AntagonistsEndothelin Receptor AntagonistsHeme Oxygenase-1IronKidneyMiceMice, KnockoutReceptor, Endothelin AEndothelin-1Endothelin A Receptor AntagonistsEndothelin Receptor AntagonistsHeme Oxygenase-1IronReceptor, Endothelin Aanémie falciformeendothelin-1endothéline-1ferroportin-1ferroportine 1homéostasie du feriron homeostasissickle cell disease

Identifiers

PMID35413222
PMCPMC10164438
OpenAlexW4223473609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.