ArticleProceedings of the National Academy of Sciences of the United States of America2022
Pathogen-induced biosynthetic pathways encode defense-related molecules in bread wheat.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Mechanisms and Advances in Plant Lipid Regulatory Responses Under Biotic and Abiotic Stress.Genes · 2026Review
- TaMPK3 mediates synergistic damage from Fusarium crown rot and drought in wheat.Nature communications · 2026Article
- The TaMADS2-TaTBL21 Module Enhances Wheat Resistance to Stripe Rust by Activating TaGKL-Mediated Immunity.Plant biotechnology journal · 2026Article
- Identification of Stress-Induced Biosynthetic Gene Clusters in Plants.Methods in molecular biology (Clifton, N.J.) · 2026Article
- TaWAKL8-2B, a wall-associated receptor-like kinase, mediates wheat rust resistance by linalool and ROS accumulation.Stress biology · 2025Article
- Characterization of switchgrass (Panicum virgatum L.) PvKSL1 as a levopimaradiene/abietadiene-type diterpene synthase.Plant biology (Stuttgart, Germany) · 2025Article
- A molecular representation system with a common reference frame for analyzing triterpenoid structural diversity.Plant communications · 2025Article
- Biosynthesis and functions of triterpenoids in cereals.Journal of advanced research · 2025Review
- Evolution and diversification of the momilactone biosynthetic gene cluster in the genus Oryza.The New phytologist · 2025Article
- Metabolomic Analysis Reveals the Diversity of Defense Metabolites in Nine Cereal Crops.Plants (Basel, Switzerland) · 2025Article
- Unleashing plant synthetic capacity: navigating regulatory mechanisms for enhanced bioproduction and secondary metabolite discovery.Current opinion in biotechnology · 2024Review
- A fungal endophyte induces local cell wall-mediated resistance in wheat roots against take-all disease.Frontiers in plant science · 2024Article
- Genetic basis and selection of glyceollin elicitation in wild soybean.Frontiers in plant science · 2024Article
- Genomic view of the origins of cell-mediated immunity.Immunogenetics · 2023Article
- LHP1-mediated epigenetic buffering of subgenome diversity and defense responses confers genome plasticity and adaptability in allopolyploid wheat.Nature communications · 2023Article
- Discovery of isoflavone phytoalexins in wheat reveals an alternative route to isoflavonoid biosynthesis.Nature communications · 2023Article
- Bioactive Steroids Bearing Oxirane Ring.Biomedicines · 2023Review
- Plant (di)terpenoid evolution: from pigments to hormones and beyond.Natural product reports · 2023Review
- Complex scaffold remodeling in plant triterpene biosynthesis.Science (New York, N.Y.) · 2023Article
- Dual RNA-sequencing of Fusarium head blight resistance in winter wheat.Frontiers in plant science · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 2 institutions in 3 countries.
Funding
Abstract
Wheat is a widely grown food crop that suffers major yield losses due to attack by pests and pathogens. A better understanding of biotic stress responses in wheat is thus of major importance. The recently assembled bread wheat genome coupled with extensive transcriptomic resources provides unprecedented new opportunities to investigate responses to pathogen challenge. Here, we analyze gene coexpression networks to identify modules showing consistent induction in response to pathogen exposure. Within the top pathogen-induced modules, we identify multiple clusters of physically adjacent genes that correspond to six pathogen-induced biosynthetic pathways that share a common regulatory network. Functional analysis reveals that these pathways, all of which are encoded by biosynthetic gene clusters, produce various different classes of compounds—namely, flavonoids, diterpenes, and triterpenes, including the defense-related compound ellarinacin. Through comparative genomics, we also identify associations with the known rice phytoalexins momilactones, as well as with a defense-related gene cluster in the grass model plant Brachypodium distachyon. Our results significantly advance the understanding of chemical defenses in wheat and open up avenues for enhancing disease resistance in this agriculturally important crop. They also exemplify the power of transcriptional networks to discover the biosynthesis of chemical defenses in plants with large, complex genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.