Evidence map›Paper›PMID 35412807›Full record

ArticleACS chemical biology2022

Chemically Modified Bacterial Sacculi as a Vaccine Microparticle Scaffold.

Payton A-B Weidenbacher, Frances P Rodriguez-Rivera, Mrinmoy Sanyal, Joshua A Visser, Jonathan Do, Carolyn R Bertozzi, Peter S Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Payton A-B WeidenbacherStanford ChEM-H, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-7692-0458
Frances P Rodriguez-RiveraStanford ChEM-H, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-0651-8639
Mrinmoy SanyalStanford ChEM-H, Stanford University, Stanford, California 94305, United States.
Joshua A VisserStanford ChEM-H, Stanford University, Stanford, California 94305, United States.
Jonathan DoStanford ChEM-H, Stanford University, Stanford, California 94305, United States.
Carolyn R BertozziStanford ChEM-H, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-4482-2754
Peter S KimStanford ChEM-H, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-6503-4541

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine scaffolds and carrier proteins increase the immunogenicity of subunit vaccines. Here, we developed, characterized, and demonstrated the efficacy of a novel microparticle vaccine scaffold comprised of bacterial peptidoglycan (PGN), isolated as an entire sacculi. The PGN microparticles contain bio-orthogonal chemical handles allowing for site-specific attachment of immunogens. We first evaluated the purification, integrity, and immunogenicity of PGN microparticles derived from a variety of bacterial species. We then optimized PGN microparticle modification conditions;

Indexed as

COVID-19SARS-CoV-2HumansPeptidoglycanStaphylococcus aureusVaccines, ConjugateVaccines, SubunitPeptidoglycanVaccines, ConjugateVaccines, Subunit

Identifiers

PMID35412807
PMCPMC9127789

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.