Evidence map›Paper›PMID 35412435›Full record

ArticleChannels (Austin, Tex.)2022

Capsaicin as an amphipathic modulator of Na

Luke M Cowan, Peter R Strege, Radda Rusinova, Olaf S Andersen, Gianrico Farrugia, Arthur Beyder

Open access · goldAbstract read
In one paragraph

Article in Channels (Austin, Tex.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Late IMedicinal research reviews · 2026
    Review
  2. Article
  3. Capsaicin: beyond TRPV1.Frontiers in nutrition · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Luke M CowanDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program (ENSP), Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5512-1227
Peter R StregeDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program (ENSP), Mayo Clinic, Rochester, MN, USA.
Radda RusinovaDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.
Olaf S AndersenDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.
Gianrico FarrugiaDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program (ENSP), Mayo Clinic, Rochester, MN, USA.
Arthur BeyderDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program (ENSP), Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-9225-4854
Mayo Clinic · USCornell University · US

Funding

Energetics of Channel-Bilayer InteractionsR01GM021342 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANDERSEN, OLAF S. · 1985 to 2021
$9.9M
MECHANOTRANSDUCTION IN INTESTINAL SMOOTH MUSCLE CELLSR01DK052766 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR, FARRUGIA, GIANRICO · 1997 to 2025
$8.3M
Does the gut have a sense of touch?DP2AT010875 · NCCIH · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2019 to 2019
$2.4M
Mechanisms of mechanotransduction in the enterochromaffin cellsK08DK106456 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2015 to 2019
$813k
NCCIH NIH HHS DP2 AT010875NIDDK NIH HHS K08 DK106456NIDDK NIH HHS R01 DK052766NIGMS NIH HHS R01 GM021342
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ChannelopathiesNAV1.5 Voltage-Gated Sodium ChannelCapsaicinHumansMyocytes, CardiacSodiumCapsaicinNAV1.5 Voltage-Gated Sodium ChannelSodiumAmphipathicarrhythmiacapsaicinelectrophysiologyfunctional gastrointestinal disorderion channelirritable bowel syndromemechanosensitivitymechanotransductionvoltage-gated sodium channel type 5

Identifiers

PMID35412435
PMCPMC9009938
OpenAlexW4223476731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.