ArticleRadiology2022
Optimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05846035 (Paraneoplastic Syndrome in Hepatocellular Carcinoma Patients), which is not on this map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Paraneoplastic Syndrome in Hepatocellular Carcinoma Patients
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Short-term efficacy assessment of transarterial chemoembolization combined with radioactive iodine therapy in primary hepatocellular carcinoma.World journal of gastrointestinal surgery · 2023Trial
- Establishing selection criteria for male New Zealand white rabbits in interventional radiology research using organ volumes and vessel diameters.European radiology experimental · 2026Article
- mpMRI-based habitat analysis for predicting prognoses in patients with high-grade serous ovarian cancer: a multicenter study.Abdominal radiology (New York) · 2025Article
- Analysis of factors influencing tumor volume doubling time in hepatocellular carcinoma and its predictive value for progression-free survival.Scientific reports · 2025Article
- AI-Based Quantification of Enhancing Tumor Volume on Contrast-Enhanced MRI to Predict Pathologic Response and Prognosis in HCC After HAIC Plus Targeted Therapy and Immunotherapy.Journal of hepatocellular carcinoma · 2025Article
- Comparative Effectiveness and Safety of Molecular Targeted Therapy Plus PD-(L)1 with or without TACE in Unresectable Hepatocellular Carcinoma: A Retrospective Study.ImmunoTargets and therapy · 2025Article
- MRI Parameters and Clinicopathologic Features in Predicting Hepatocellular Carcinomas With Aggressive-Related Marker Expression, Defined by Epithelial Cell Adhesion Molecule and Glypican-3 Status.International journal of general medicine · 2025Article
- Identification ofFrontiers in molecular biosciences · 2025Article
- TOP2A as a prognostic biomarker in small cell carcinoma of the esophagus: an integrated bioinformatics and immunohistochemical study.Frontiers in molecular biosciences · 2025Article
- Identification of proliferative hepatocellular carcinoma using the SMARS score and implications for microwave ablation.Insights into imaging · 2024Article
- AI-derived body composition parameters as prognostic factors in patients with HCC undergoing TACE in a multicenter study.JHEP reports : innovation in hepatology · 2024Article
- Predicting Survival Using Whole-Liver MRI Radiomics in Patients with Hepatocellular Carcinoma After TACE Refractoriness.Cardiovascular and interventional radiology · 2024Article
- Prognostic Value of Preoperative MRI-derived 3D Quantitative Tumor Arterial Burden in Patients with Hepatocellular Carcinoma Receiving Transarterial Chemoembolization.Radiology. Imaging cancer · 2024Article
- Actuality and underlying mechanisms of systemic immune-inflammation index and geriatric nutritional risk index prognostic value in hepatocellular carcinoma.World journal of gastrointestinal surgery · 2024Article
- Survival Benefit of Lenvatinib Plus PD-1 Inhibitor with or Without HAIC in Advanced Hepatocellular Carcinoma Beyond Oligometastasis: a Multicenter Cohort Study.ImmunoTargets and therapy · 2024Article
- Correlation between preoperative systemic immune inflammation index, nutritional risk index, and prognosis of radical resection of liver cancer.World journal of gastrointestinal surgery · 2023Article
- Identification of NOX4 as a New Biomarker in Hepatocellular Carcinoma and Its Effect on Sorafenib Therapy.Biomedicines · 2023Article
- Comparison of quantitative volumetric analysis and linear measurement for predicting the survival of Barcelona Clinic Liver Cancer 0- and A stage hepatocellular carcinoma after radiofrequency ablation.Diagnostic and interventional radiology (Ankara, Turkey) · 2023Article
- Local anaesthesia vs. general anaesthesia for percutaneous microwave ablation in hepatocellular carcinoma: efficacy, safety, and cost analysis.Frontiers in oncology · 2023Article
- Prognostic Factors for Patients with Proliferative Hepatocellular Carcinoma After Liver Resection.Journal of hepatocellular carcinoma · 2023Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 3 countries.
Tabea BordeFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0003-3019-5470
Nariman NezamiFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0002-8829-1548
Fabian Laage GauppFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0001-6940-9793
Lynn Jeanette SavicFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0003-2115-6728
Tamar TaddeiFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0002-6500-1739
Ariel JaffeFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
Mario StrazzaboscoFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0002-1995-6331
MingDe LinFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0001-7641-2595
Rafael DuranFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0003-2610-9517
Christos GeorgiadesFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).
Kelvin HongFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0002-8420-5307
Julius ChapiroFrom the Department of Radiology and Biomedical Imaging (T.B., N.N., F.L.G., L.J.S., M.L., J.C.) and Department of Medicine, Section of Digestive Diseases (T.T., A.J., M.S.), Yale University School of Medicine, 330 Cedar St, TE 2-230, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany (T.B.); Division of Vascular and Interventional Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Md (N.N., R.D., C.G., K.H., J.C.); Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Ga (N.N.); Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (L.J.S.); Visage Imaging, San Diego, Calif (M.L.); and Lausanne University Hospital and University of Lausanne, Department of Radiology and Interventional Radiology, Lausanne, Switzerland (R.D.).ORCID 0000-0002-1984-2246
Johns Hopkins University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MQuantitative Multimodal Imaging Biomarkers for Combined Locoregional and Immunotherapy of Liver CancerR01CA206180 · NCI · YALE UNIVERSITY · PI CHAPIRO, JULIUS, DUNCAN, JAMES S · 2016 to 2025
$6.1MAutocrine/Paracrine Regulation of Intrahepatic Bile Duct GrowthI01BX000574 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2009 to 2022
–BLR&D Research Career Scientist AwardIK6BX004601 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2019 to 2025
–BLRD VA IK6 BX004601NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA206180NIDDK NIH HHS P30 DK034989
Abstract
Background Patients with intermediate- and advanced-stage hepatocellular carcinoma (HCC) represent a highly heterogeneous patient collective with substantial differences in overall survival. Purpose To evaluate enhancing tumor volume (ETV) and enhancing tumor burden (ETB) as new criteria within the Barcelona Clinic Liver Cancer (BCLC) staging system for optimized allocation of patients with intermediate- and advanced-stage HCC to undergo transarterial chemoembolization (TACE). Materials and Methods In this retrospective study, 682 patients with HCC who underwent conventional TACE or TACE with drug-eluting beads from January 2000 to December 2014 were evaluated. Quantitative three-dimensional analysis of contrast-enhanced MRI was performed to determine thresholds of ETV and ETB (ratio of ETV to normal liver volume). Patients with ETV below 65 cm
Indexed as
Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsBiomarkers, TumorHumansMagnetic Resonance ImagingMaleMiddle AgedNeoplasm StagingRetrospective StudiesTreatment OutcomeTumor BurdenBiomarkers, Tumor
Identifiers
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Registered trials
NCT05846035ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.