Evidence map›Paper›PMID 35412269›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

The Giant Axon of the Squid: A Simple System for Axonal Transport Studies.

Joseph A DeGiorgis, Marcus Jang, Elaine L Bearer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joseph A DeGiorgisBiology Department, Providence College, Providence, RI, USA.
Marcus JangBrown University, Providence, RI, USA.
Elaine L BearerMarine Biological Laboratory, Woods Hole, MA, USA. ebearer@salud.unm.edu.
Marine Biological Laboratory · USBrown University · US

Funding

YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 1998 to 2011
$21.9M
Scientific CoreP20AG068077 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2020 to 2022
$3.1M
Live imaging of brain circuitry in mouse models of PTSDR01MH096093 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BEARER, ELAINE L · 2012 to 2016
$2.8M
Using Transport to Map the BrainR01NS062184 · NINDS · UNIVERSITY OF NEW MEXICO · PI BEARER, ELAINE L · 2009 to 2010
$1.5M
MOLECULAR MECHANISMS OF ACTIN DYNAMICS IN PLATELETSR01GM047368 · NIGMS · BROWN UNIVERSITY · PI BEARER, ELAINE L · 1994 to 2003
$1.2M
Molecular mechanisms of anterograde transportR01NS046810 · NINDS · BROWN UNIVERSITY · PI BEARER, ELAINE L · 2004 to 2007
$1.1M
NCRR NIH HHS P41 RR013642NIA NIH HHS P20 AG068077NIGMS NIH HHS R01 GM047368NIMH NIH HHS R01 MH096093NINDS NIH HHS R01 NS046810NINDS NIH HHS R01 NS062184
6 · The paper itself

Abstract

The squid giant axon has a long history of being a superb experimental system in which to investigate a wide range of questions concerning intracellular transport. In this protocol we describe the method used for dissecting the axon to preserve its viability in vitro, and the technique for injecting exogenous materials into the living axon. Now that the squid genome is emerging, and the CRISPR/cas9 system has been successfully applied to knock-out squid genes, the giant axon will resume its place in the scientific pantheon of powerful experimental systems in which to address biological questions pertaining to all eukaryotes.

Indexed as

Axonal TransportDecapodiformesAnimalsAxonsAmyloid precursor proteinAxonal transportCytoskeletonDoryteuthis (Loligo) pealeiGiant axonHerpes simplex virus type 1Intracellular transportKinesinMicrotubule-based transport

Identifiers

PMID35412269
PMCPMC13359087
OpenAlexW4226241941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.