ArticleAnnals of intensive care2022
External chest-wall compression in prolonged COVID-19 ARDS with low-compliance: a physiological study.
Article in Annals of intensive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- The "mechanical paradox" unveiled: a physiological study.Critical care (London, England) · 2025Trial
- Bedside detection of end-tidal overdistention: an exploratory comparison of loading maneuvers.Intensive care medicine experimental · 2026Article
- The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome-Lessons Learned?Journal of clinical medicine · 2024Review
- PEEP Titration Is Markedly Affected by Trunk Inclination in Mechanically Ventilated Patients with COVID-19 ARDS: A Physiologic, Cross-Over Study.Journal of clinical medicine · 2023Article
- Editorial: Lung monitoring in respiratory failure.Frontiers in medicine · 2023Article
- Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study.Respiratory research · 2022Article
- Chest wall loading in the ICU: pushes, weights, and positions.Annals of intensive care · 2022Review
- Chest wall loading during supine and prone position in patients with COVID-19 ARDS: effects on respiratory mechanics and gas exchange.Critical care (London, England) · 2022Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundExternal chest-wall compression (ECC) is sometimes used in ARDS patients despite lack of evidence. It is currently unknown whether this practice has any clinical benefit in patients with COVID-19 ARDS (C-ARDS) characterized by a respiratory system compliance (C
objectivesTo test if an ECC with a 5 L-bag in low-compliance C-ARDS can lead to a reduction in driving pressure (DP) and improve gas exchange, and to understand the underlying mechanisms.
methodsEleven patients with low-compliance C-ARDS were enrolled and underwent 4 steps: baseline, ECC for 60 min, ECC discontinuation and PEEP reduction. Respiratory mechanics, gas exchange, hemodynamics and electrical impedance tomography were recorded. Four pigs with acute ARDS were studied with ECC to understand the effect of ECC on pleural pressure gradient using pleural pressure transducers in both non-dependent and dependent lung regions.
resultsFive minutes of ECC reduced DP from baseline 14.2 ± 1.3 to 12.3 ± 1.3 cmH
conclusionsIn C-ARDS patients with C
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.