Evidence map›Paper›PMID 35412077›Full record

ArticleParasitology research2022

Roles of calpain in the apoptosis of Eimeria tenella host cells at the middle and late developmental stages.

Xiao-Zhen Cui, Ming-Xue Zheng, Shi-Yu Yang, Rui Bai, Li Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Microbiology spectrum · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Xiao-Zhen CuiCollege of Animal Medicine, Shanxi Agriculture University, Taiyuan, Shanxi Province, 030036, People's Republic of China.
Ming-Xue ZhengCollege of Animal Medicine, Shanxi Agriculture University, Taiyuan, Shanxi Province, 030036, People's Republic of China. zhengmingxue288@163.com.ORCID http://orcid.org/0000-0003-0142-4377
Shi-Yu YangDepartment of Clinical Neurosciences, UCL Institute of Neurology, Rowland Hill Street, London, NW3 2PF, UK.
Rui BaiCollege of Animal Medicine, Shanxi Agriculture University, Taiyuan, Shanxi Province, 030036, People's Republic of China.
Li ZhangCollege of Animal Medicine, Shanxi Agriculture University, Taiyuan, Shanxi Province, 030036, People's Republic of China.
Shanxi Agricultural University · CNRoland Hill (United Kingdom) · GB

Funding

key r&d projects of Shanxi Province 201903D421040National Natural Science Foundition of China 31272536
6 · The paper itself

Abstract

This study investigated the role of calpain in Eimeria tenella-induced host cell apoptosis. Chick embryo cecal epithelial cell culture technology, flow cytometry, enzyme-linked immunosorbent assays, and fluorescence quantitative PCR were used to detect the E. tenella host cell apoptotic rate, Bax and Bid expression levels, and calpain activity. The results demonstrated that Bax, Bid, and calpain levels were upregulated and apoptosis was increased following E. tenella infection at 24-120 h. Calpain levels were reduced by pharmacological inhibition of calpain using SJA6017 or by blocking Ca

Indexed as

CoccidiosisEimeria tenellaPoultry DiseasesAnimalsApoptosisbcl-2-Associated X ProteinCalpainChick EmbryoChickensbcl-2-Associated X ProteinCalpainApoptosis rateBaxBidCalpainEimeria tenella

Identifiers

PMID35412077
OpenAlexW4223464014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.