Evidence map›Paper›PMID 35411794›Full record

ArticleJournal of the American Heart Association2022

Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin-Deficient Mice.

Toshihiro Tsuruda, Atsushi Yamashita, Misa Otsu, Masanori Koide, Yuko Nakamichi, Yoko Sekita-Hatakeyama, Kinta Hatakeyama, Taro Funamoto, Etsuo Chosa, Yujiro Asada and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Aneurysm Is Restricted by CD34Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Immune and Metabolic Mechanisms of Endothelial Dysfunction.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Toshihiro TsurudaDivision of Internal Medicine, Cardiovascular Medicine and Nephrology Faculty of Medicine University of Miyazaki Japan.ORCID 0000-0002-9130-109X
Atsushi YamashitaDepartment of Pathology Faculty of Medicine University of Miyazaki Japan.ORCID 0000-0001-5487-7594
Misa OtsuDivision of Internal Medicine, Cardiovascular Medicine and Nephrology Faculty of Medicine University of Miyazaki Japan.
Masanori KoideInstitute for Oral Science Matsumoto Dental University Nagano Japan.ORCID 0000-0002-6511-9999
Yuko NakamichiInstitute for Oral Science Matsumoto Dental University Nagano Japan.ORCID 0000-0001-9887-9903
Yoko Sekita-HatakeyamaDepartment of Diagnostic Pathology Nara Medical University Nara Japan.ORCID 0000-0001-7260-0652
Kinta HatakeyamaDepartment of Pathology National Cerebral and Cardiovascular Center Osaka Japan.ORCID 0000-0001-7729-1836
Taro FunamotoDivision of Orthopedic Surgery Department of Medicine of Sensory and Motor Organs Faculty of Medicine University of Miyazaki Japan.
Etsuo ChosaDivision of Orthopedic Surgery Department of Medicine of Sensory and Motor Organs Faculty of Medicine University of Miyazaki Japan.
Yujiro AsadaDepartment of Pathology Faculty of Medicine University of Miyazaki Japan.ORCID 0000-0001-5105-2159
Nobuyuki UdagawaDepartment of Biochemistry Matsumoto Dental University Nagano Japan.
Johji KatoFrontier Science Research Center University of Miyazaki Japan.
Kazuo KitamuraFrontier Science Research Center University of Miyazaki Japan.
University of Miyazaki · JPMatsumoto Dental University · JPNara Medical University · JPNational Cerebral and Cardiovascular Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The biological mechanism of action for osteoprotegerin, a soluble decoy receptor for the receptor activator of nuclear factor-kappa B ligand in the vascular structure, has not been elucidated. The study aim was to determine if osteoprotegerin affects aortic structural integrity in angiotensin II (Ang II)-induced hypertension. Methods and Results Mortality was higher (

Indexed as

Aortic DissectionAortic RuptureHypertensionAngiotensin IIAnimalsDisease Models, AnimalElastinMaleMiceMice, Inbred C57BLMice, KnockoutOsteoprotegerinRANK LigandAngiotensin IIElastinOsteoprotegerinRANK Ligandaortic dissectionelastinextracellular matrixproteoglycan

Identifiers

PMID35411794
PMCPMC9238451
OpenAlexW4223483655

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.