ArticleHuman brain mapping2022
Association between stressful life events and grey matter volume in the medial prefrontal cortex: A 2-year longitudinal study.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Resilience beyond diagnosis: prospective neural correlates of better-than-expected outcomes in depression.Molecular psychiatry · 2026Article
- History of childhood trauma enhances the detrimental effects of recent stressors on brain structure and function in major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder.JAMA network open · 2026Article
- Can Sodium Oxybate Mitigate the Symptoms of Schizophrenia?Current neuropharmacology · 2026Review
- Chronic unpredictable stress produces hyperalgesia and promotes inhibitory drive in medial prefrontal cortex.The journal of pain · 2025Article
- The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The association between childhood adversity and hippocampal volumes is moderated by romantic relationship experiences.The European journal of neuroscience · 2025Article
- Influences of sex and gender on the associations between risk and protective factors, brain, and behavior.Biology of sex differences · 2024Review
- Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls.Molecular psychiatry · 2024Article
- Childhood and Adulthood Trauma Associate With Cognitive Aging Among Black and White Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Rewarded Maze Training Increases Approach Behavior in Rats Through Neurogenesis-Dependent Growth of Ventral Hippocampus-Prelimbic Circuits.Biological psychiatry global open science · 2023Article
- Brain Changes Linked to Cognitive Symptomatology in Homeless Youth.Clinical nursing research · 2023Article
- Association between stressful life events and grey matter volume in the medial prefrontal cortex: A 2-year longitudinal study.Human brain mapping · 2022Article
- Regional gray matter volume mediates the relationship between neuroticism and depressed emotion.Frontiers in psychology · 2022Article
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Authors and funding
20 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Stressful life events (SLEs) in adulthood are a risk factor for various disorders such as depression, cancer or infections. Part of this risk is mediated through pathways altering brain physiology and structure. There is a lack of longitudinal studies examining associations between SLEs and brain structural changes. High-resolution structural magnetic resonance imaging data of 212 healthy subjects were acquired at baseline and after 2 years. Voxel-based morphometry was used to identify associations between SLEs using the Life Events Questionnaire and grey matter volume (GMV) changes during the 2-year period in an ROI approach. Furthermore, we assessed adverse childhood experiences as a possible moderator of SLEs-GMV change associations. SLEs were negatively associated with GMV changes in the left medial prefrontal cortex. This association was stronger when subjects had experienced adverse childhood experiences. The medial prefrontal cortex has previously been associated with stress-related disorders. The present findings represent a potential neural basis of the diathesis-stress model of various disorders.
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