ArticleAnnals of biomedical engineering2022
Effects of MitraClip Therapy on Mitral Flow Patterns and Vortex Formation: An In Vitro Study.
Article in Annals of biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 6 citations in OpenAlex.
- Personalized tricuspid valve modeling predicts regurgitation biomechanical repair and double‑orifice flow.Physical and engineering sciences in medicine · 2026Article
- Development and feasibility testing of a dynamic image-derived simulation framework for assessing left atrioventricular valve repair strategies.International journal of computer assisted radiology and surgery · 2026Article
- Mitral Valve Repair vs. Replacement: Hemodynamics in Valve Surgery.Reviews in cardiovascular medicine · 2026Review
- Reply to Comment on "Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features".Cardiovascular engineering and technology · 2025Article
- Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features.Cardiovascular engineering and technology · 2025Article
- Experimental Investigation of the Effect of a MitraClip on Left Ventricular Flow Dynamics.Annals of biomedical engineering · 2025Article
- Intracardiac flow dynamics in mitral regurgitation: state of the art.European heart journal. Imaging methods and practice · 2025Review
- Intracardiac fluid dynamic analysis: available techniques and novel clinical applications.BMC cardiovascular disorders · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
MitraClip transcatheter edge-to-edge repair is used to treat mitral regurgitation (MR). While MR is reduced, diastolic left ventricular flows are altered. An in vitro left heart simulator was used to assess a porcine mitral valve in the native, MR, and MR plus MitraClip cases. Velocity, vorticity, and Reynolds shear stress (RSS) were quantified by particle image velocimetry. Peak velocity increased from 1.20 m/s for native to 1.30 m/s with MR. With MitraClip, two divergent jets of 1.18 and 0.61 m/s emerged. Higher vorticity was observed with MR than native and lessened with MitraClip. MitraClip resulted in shear layer formation and downstream vortex formation. Native RSS decreased from 33 Pa in acceleration to 29 Pa at peak flow, then increased to 31 Pa with deceleration. MR RSS increased from 27 Pa in acceleration to 40 Pa at peak flow to 59 Pa during deceleration. MitraClip RSS increased from 79 Pa in acceleration to 162 Pa during peak flow, then decreased to 45 Pa during deceleration. After MitraClip, two divergent jets of reduced velocity emerged, accompanied by shear layers and recirculation. Chaotic flow developed, resulting in elevated RSS magnitude and coverage. Findings help understand consequences of MitraClip on left ventricular flow dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.