ArticleScandinavian journal of work, environment & health2022
Interaction of night shift work with polymorphism in melatonin receptor 1B gene on incident stroke.
Article in Scandinavian journal of work, environment & health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Association of non-standard working time arrangements with safety incidents: a systematic review.BMJ open · 2025Pooled it
- Role of Life's Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants.Journal of global health · 2026Article
- The association of night shift work with the risk of acute ischemic cerebrovascular syndrome: a longitudinal study of 204,261 UK Biobank participants.Journal of neurology · 2026Article
- Emergency radiology: an evolving subspecialty facing rapid growth and unique stressors, with a path toward sustainable clinical practice.Emergency radiology · 2026Review
- The G-allele of rs10830963 inInternational journal of molecular sciences · 2025Article
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Working hours and health - key research topics in the past and future.Scandinavian journal of work, environment & health · 2024Review
- Article
- Myocardial Infarction Susceptibility and theInternational journal of molecular sciences · 2023Article
- Circadian Factors in Stroke: A Clinician's Perspective.Cardiology and therapy · 2023Review
- Uncovering Novel Biomarkers of Inflammation as Potential Screening Targets of Disease Risk in Healthcare Shift Workers: A Pilot Study.International journal of nursing and health care research · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesThe aim of this study was to investigate whether melatonin receptor type 1B (MTNR1B) rs10830963 polymorphism interacts with night shift work on the risk of incident stroke.
methodsThis study included individuals free of stroke at baseline from the UK Biobank. Night-shift work was assessed by the self-reported questions. MTNR1B rs10830963 was directly genotyped (CC, GC, and GG). Incident stroke was ascertained through hospital records and death registries. Cox proportional hazards models were employed to examine the associations of night shift work and MTNR1B rs10830963 with the risk of incident stroke.
resultsA total of 242 194 participants were finally included (mean age: 52.95 years; 51.63% women). Over 12-year follow-up, 3287 incident stroke events occurred. Night shift work increased the risk of incident stroke [hazard ratio (HR) 1.13, 95% confidence interval (CI) 1.00-1.28] after adjusting for socio-demographics, and this association attenuated after additional adjustment for lifestyle factors (HR 1.06, 95% CI 0.94-1.20). MTNR1B rs10830963 polymorphism modified the association between night shift work and incident stroke (Pfor interaction =0.010). In the Cox models adjusted for socio-demographics and lifestyle factors, among night-shift workers, minor allele G was associated with a reduced risk of incident stroke (GC versus CC, HR 0.74, 95% CI 0.58-0.95; GG versus CC, HR 0.65, 95% CI 0.40-1.06; P for trend=0.010); while night shift work was associated with a higher stroke risk only among MTNR1B rs10830963 CC carriers (HR 1.23, 95% CI 1.05-1.44) but not GC/GG carriers.
conclusionsThese results suggest that MTNR1B rs10830963 may potentially modify the associations between night shift work and incident stroke.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.