ArticleJACC. Basic to translational science2022
TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis.
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Article in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Mitochondria Take Up and Dispose of Cytosolic Protein Aggregates.Circulation research · 2026Article
- Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function.Circulation research · 2026Article
- Disrupted Mitochondrial Quality Control in Atherosclerotic Disease: Mitophagy and Dynamics in Focus.JACC. Basic to translational science · 2026Review
- Two Routes for Removing Unhealthy Mitochondria: Degradation and Secretion.Circulation research · 2026Review
- Mastering cardiomyocyte mitophagy: molecular governance, pathological derailment and therapeutics.PeerJ · 2026Review
- Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling.The Journal of clinical investigation · 2025Article
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- Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy.Circulation research · 2024Article
- α-Ketoglutarate improves cardiac insufficiency through NADMolecular medicine (Cambridge, Mass.) · 2024Article
- Cardiac radiation improves ventricular function in mice and humans with cardiomyopathy.Med (New York, N.Y.) · 2023Article
- The natural compound Sanggenon C inhibits PRRSV infection by regulating the TRAF2/NF-κB signalling pathway.Veterinary research · 2023Article
- Mitophagy for cardioprotection.Basic research in cardiology · 2023Review
- Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer.Journal of translational medicine · 2023Review
- Preserving mitochondria to treat hypertrophic cardiomyopathy: From rare mitochondrial DNA mutation to heart failure therapy?The Journal of clinical investigation · 2023Article
- Characterizing and Quenching Autofluorescence in Fixed Mouse Adrenal Cortex Tissue.International journal of molecular sciences · 2023Article
- Cardiovascular hemodynamics in mice with tumor necrosis factor receptor-associated factor 2 mediated cytoprotection in the heart.Frontiers in cardiovascular medicine · 2023Article
- Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure.JACC. Basic to translational science · 2022Article
- Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy.Circulation · 2022Article
- TRAF2 Mediates Physiological Mitophagy.JACC. Basic to translational science · 2022Article
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Authors and funding
21 authors at 6 institutions in 2 countries.
Xiucui MaCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
David R RawnsleyCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Attila KovacsCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Moydul IslamCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
John T MurphyCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Chen ZhaoCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Minu KumariCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Layla ForoughiCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Haiyan LiuCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Kevin QiCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Aaradhya DiwanCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Krzysztof HyrcAlafi Neuroimaging Laboratory, Washington University School of Medicine, St. Louis, Missouri, USA.
Sarah EvansCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Takashi SatohDepartment of Immune Regulation, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Brent A FrenchDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Kenneth B MarguliesDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ali JavaheriCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Babak RazaniCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Douglas L MannCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Kartik ManiCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Abhinav DiwanCenter for Cardiovascular Research and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Washington University in St. Louis · USJohn Cochran VA Medical Center · USHope Center for Neurological Disorders · USTokyo Medical and Dental University · JPUniversity of Pennsylvania · USUniversity of Virginia · US
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2013 to 2026
$27.1MPRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6MROLE OF AUTOPHAGIC FLUX IN CARDIAC MYOCYTE VIABILITYR01HL107594 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan · 2011 to 2026
$5.9MHIGH-RESOLUTON ULTRASOUND SYSTEM FOR PHENOTYPIC EVALUATION OF THE CARDIOVASCULAR SYSTEM IN MICES10OD028597 · OD · WASHINGTON UNIVERSITY · PI KOVACS, ATTILA · 2020 to 2020
$378kTargeting Macrophage Lysosome Biogenesis Program in Cardiomyopathy and Heart FailureI01BX004235 · VA · ST. LOUIS VA MEDICAL CENTER · PI DIWAN, ABHINAV · 2018 to 2021
–Enhancing Beneficial Autophagy to Prevent Heart FailureI01BX001969 · VA · ST. LOUIS VA MEDICAL CENTER · PI DIWAN, ABHINAV · 2014 to 2017
–BLRD VA I01 BX001969BLRD VA I01 BX004235NHLBI NIH HHS R01 HL107594NHLBI NIH HHS T32 HL007081NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIH HHS S10 OD028597
Abstract
Mitochondria are essential for cardiac myocyte function, but damaged mitochondria trigger cardiac myocyte death. Although mitophagy, a lysosomal degradative pathway to remove damaged mitochondria, is robustly active in cardiac myocytes in the unstressed heart, its mechanisms and physiological role remain poorly defined. We discovered a critical role for TRAF2, an innate immunity effector protein with E3 ubiquitin ligase activity, in facilitating physiological cardiac myocyte mitophagy in the adult heart, to prevent inflammation and cell death, and maintain myocardial homeostasis.
Indexed as
AAV9, adeno-associated virus serotype 9cell deathcTnT, cardiac troponin TER, endoplasmic reticulumFS, fractional shorteningGFP, green fluorescent proteininflammationIP, intraperitonealLV, left ventricularMAM, mitochondria-associated membranesMCM, MerCreMerMEF, murine embryonic fibroblastmitophagyPINK1, PTEN-induced kinase 1RFP, red fluorescent proteinTLR9, toll-like receptor 9TRAF2TRAF2, tumor necrosis factor receptor-associated factor-2TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.