Evidence map›Paper›PMID 35411324›Full record

ReviewJACC. Basic to translational science2022

Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.

Reena Mehra, Olga A Tjurmina, Olujimi A Ajijola, Rishi Arora, Donald C Bolser, Mark W Chapleau, Peng-Sheng Chen, Colleen E Clancy, Brian P Delisle, Michael R Gold and 19 more

Open access · goldAbstract readReview
In one paragraph

Review in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Glia of the heart's nervous system.Nature reviews. Neuroscience · 2025
    Review
  13. Research Progress of BMAL1 in Heart Failure.Journal of the American Heart Association · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Nonlinear Association Between Weekday Sleep Duration and COPD Risk: Evidence From NHANES 2017-2023.International journal of chronic obstructive pulmonary disease · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 3 countries.

Reena MehraCleveland Clinic, Cleveland, Ohio, USA.
Olga A TjurminaNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Olujimi A AjijolaDavid Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Rishi AroraFeinberg School of Medicine at Northwestern University, Chicago, Illinois, USA.
Donald C BolserUniversity of Florida, Gainesville, Florida, USA.
Mark W ChapleauUniversity of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Peng-Sheng ChenCedars-Sinai Medical Center, Los Angeles, California, USA.
Colleen E ClancyUniversity of California Davis, Davis, California, USA.
Brian P DelisleUniversity of Kentucky, Lexington, Kentucky, USA.
Michael R GoldMedical University of South Carolina, Charleston, South Carolina, USA.
Jeffrey J GoldbergerUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
David S GoldsteinNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Beth A HabeckerOregon Health and Science University School of Medicine, Portland, Oregon, USA.
M Louis HandokoAmsterdam University Medical Centers, Amsterdam, the Netherlands.
Robert HarveyUniversity of Nevada Reno, Reno, Nevada, USA.
James P HummelYale University School of Medicine, New Haven, Connecticut, USA.
Thomas HundOhio State University, Columbus, Ohio, USA.
Christian MeyerUniversity of Düsseldorf, Germany, Düsseldorf, Germany.
Susan RedlineHarvard Medical School, Boston, Massachusetts, USA.
Crystal M RipplingerUniversity of California Davis School of Medicine, Davis, California, USA.
Marc A SimonUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Virend K SomersMayo Clinic, Rochester, Minnesota, USA.
Stavros StavrakisUniversity of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Thomas Taylor-ClarkUniversity of South Florida, Tampa, Florida, USA.
Bradley Joel UndemJohns Hopkins University, Baltimore, Maryland, USA.
Richard L VerrierBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Irving H ZuckerUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
George SopkoNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Kalyanam ShivkumarDavid Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Harvard University · USNational Heart Lung and Blood Institute · USUniversity of California, Davis · USUniversity of California, Los Angeles · USAmsterdam University Medical Centers · NLCase Western Reserve University · USCedars-Sinai Medical Center · USHeinrich Heine University Düsseldorf · DEJohns Hopkins University · USMayo Clinic · USMedical University of South Carolina · USNational Institute of Neurological Disorders and Stroke · USNorthwestern University · USOregon Health & Science University · USThe Ohio State University · USUniversity of Florida · USUniversity of Iowa · USUniversity of Kentucky · USUniversity of Miami · USUniversity of Nebraska Medical Center · US

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA · 2019 to 2026
$21.1M
Functional mapping of peripheral and central circuits for airway protection and breathingOT2OD023854 · OD · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C · 2016 to 2020
$10.8M
Neurotrophins and post-infarct plasticity in cardiac sympathetic neuronsR01HL093056 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETH A HABECKER · 2009 to 2026
$7.9M
The Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1M
Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
Peripheral Sympathetic Dysfunction in Cardiac DiseaseR01HL146833 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETH A HABECKER · 2020 to 2026
$5.1M
Modeling the role of the NTS in the neurogenesis of airway defensive behaviorsR01HL131716 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, MORRIS, KENDALL FRANCIS · 2017 to 2020
$3.1M
Central and Peripheral Regulation of Laryngeal AdductionR01HL163008 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, PITTS, TERESA G · 2022 to 2025
$2.8M
Influence of Opioids on the Brainstem Respiratory NetworkR01HL155721 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, MORRIS, KENDALL FRANCIS · 2021 to 2024
$2.7M
Comparative mapping of functionally distinct visceral afferent nociceptive pathwaysU01NS113868 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI KOLLARIK, MARIAN, TAYLOR-CLARK, THOMAS EDWARD · 2019 to 2021
$2.2M
Remodeled airway irritant reflexes as a cause of serious cardiovascular eventsR01HL152219 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD · 2021 to 2024
$2.1M
Identification and Activation Mechanisms of Vagal and Spinal Nociceptors in Esophageal MucosaR01DK110366 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD, YU, SHAOYONG · 2017 to 2020
$1.4M
NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL093056NHLBI NIH HHS R01 HL111600NHLBI NIH HHS R01 HL131716NHLBI NIH HHS R01 HL146833NHLBI NIH HHS R01 HL152219NHLBI NIH HHS R01 HL155721NIDDK NIH HHS R01 DK110366NIDDK NIH HHS R21 DK124894NIDDK NIH HHS U01 DK116311NIH HHS OT2 OD023854NIH HHS OT2 OD026580NINDS NIH HHS U01 NS113868
6 · The paper itself

Abstract

This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.

Indexed as

ACE, angiotensin-converting enzymeAch, acetylcholineAD, autonomic dysregulationAF, atrial fibrillationANS, autonomic nervous systemasthmaatrial fibrillationautonomic nervous systemcardiopulmonarychronic obstructive pulmonary diseasecircadianCNS, central nervous systemCOPD, chronic obstructive pulmonary diseaseCSA, central sleep apneaCVD, cardiovascular diseaseECG, electrocardiogramEV, extracellular vesicleGP, ganglionated plexiheart failureHF, heart failureHFpEF, heart failure with preserved ejection fractionHFrEF, heart failure with reduced ejection fractionHRV, heart rate variabilityLQT, long QTMI, myocardial infarctionNE, norepinephrineNHLBI, National Heart, Lung, and Blood InstituteNPY, neuropeptide YNREM, non-rapid eye movementOSA, obstructive sleep apneaPAH, pulmonary arterial hypertensionpulmonary arterial hypertensionPV, pulmonary veinREM, rapid eye movementRV, right ventricularSCD, sudden cardiac deathSDB, sleep disordered breathingsleep apneaSNA, sympathetic nerve activitySNSA, sympathetic nervous system activityTLD, targeted lung denervationventricular arrhythmia

Identifiers

PMID35411324
PMCPMC8993767
OpenAlexW4210775997

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.