Evidence map›Paper›PMID 35411290›Full record

ArticleEuropean physical journal plus2022

Validation of circular dichroic spectroscopy of synthetic oligonucleotide PS2.M for

Luca Bruni, Massimo Manghi, Paola De Sanctis, Cinzia Zucchini, Simonetta Croci

Abstract read
In one paragraph

Article in European physical journal plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luca BruniNational Institute for Biostructures and Biosystems, Rome, Italy.
Massimo ManghiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Paola De SanctisDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Università di Bologna, Bologna, Italy.
Cinzia ZucchiniDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Università di Bologna, Bologna, Italy.
Simonetta CrociNational Institute for Biostructures and Biosystems, Rome, Italy.ORCID 0000-0003-4792-1416

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The single-stranded synthetic oligonucleotide PS2.M is known to provide a basis for developing sensors since it tends to fold into structures called G-quadruplexes (G4) having characteristic topology and orientation with probabilities that depend on the chemical environment. The presence and concentration of cation species are among the key factors that determine the outcome of such a process. PS2.M and other aptamers have been used in several applications in conjunction with various probes, such as hemin, at the cost of increased technical complexity and applicability limitations. We instead validated the application limits of Circular Dichroic spectroscopy (CD) as only measurement method to assay PS2.M as Supplementary Information: The online version supplementary material available at 10.1140/epjp/s13360-022-02581-2.

Identifiers

PMID35411290
PMCPMC8988120

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.