Evidence map›Paper›PMID 35411225›Full record

ArticleAmerican journal of cancer research2022

EPHB2 expression is associated with intestinal phenotype of gastric cancer and indicates better prognosis by suppressing gastric cancer migration.

Hyesung Kim, Jae Kyung Myung, Seung Sam Paik, Hyunsung Kim, Hosub Park, Yeon Ju Kim, Seung Bum Lee, Heung Up Kim, Hyun Joo Song, In Ho Jeong and 5 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Hyesung KimDepartment of Pathology, Jeju National University School of Medicine and Jeju National University Hospital Jeju, South Korea.
Jae Kyung MyungDepartment of Pathology, Hanyang University College of Medicine Seoul, South Korea.
Seung Sam PaikDepartment of Pathology, Hanyang University College of Medicine Seoul, South Korea.
Hyunsung KimDepartment of Pathology, Hanyang University College of Medicine Seoul, South Korea.
Hosub ParkDepartment of Pathology, Hanyang University College of Medicine Seoul, South Korea.
Yeon Ju KimDepartment of Life Science, Research Institute for Natural Sciences, Hanyang University Seoul, South Korea.
Seung Bum LeeLaboratory of Radiation Exposure and Therapeutics, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Science Seoul, South Korea.
Heung Up KimDepartment of Internal Medicine, Jeju National University School of Medicine and Jeju National University Hospital Jeju, South Korea.
Hyun Joo SongDepartment of Internal Medicine, Jeju National University School of Medicine and Jeju National University Hospital Jeju, South Korea.
In Ho JeongDepartment of Surgery, Jeju National University School of Medicine and Jeju National University Hospital Jeju, South Korea.
Suji HongDepartment of Pathology, Jeju National University School of Medicine and Jeju National University Hospital Jeju, South Korea.
Chul Min ParkDepartment of Obstetrics & Gynecology, Jeju National University School of Medicine Jeju, South Korea.
Cheol LeeDepartment of Pathology, Seoul National University College of Medicine Seoul, South Korea.
Younghoon KimLaboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine Seoul, South Korea.
Bogun JangDepartment of Pathology, Jeju National University School of Medicine and Jeju National University Hospital Jeju, South Korea.
Jeju National University Hospital · KRHanyang University · KRCancer Research Institute · USJeju National University · KRKorea Institute of Radiological and Medical Sciences · KRNew Generation University College · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The protein tyrosine kinase Ephrin type-B receptor 2 (EPHB2) belongs to one of the intestinal stem cell signature genes and plays a crucial role in maintaining the crypt-villous axis. Herein, we aimed to investigate the expression of EPHB2 during gastric carcinogenesis and evaluated its prognostic and functional significance in gastric cancer (GC). EPHB2 expression was upregulated in intestinal metaplasia and GCs compared to normal antral and fundic glands.

Indexed as

EPHB2gastric cancerimmunohistochemistryprognosis

Identifiers

PMID35411225
PMCPMC8984899
OpenAlexW4226184182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.