Evidence map›Paper›PMID 35411113›Full record

Observational studyNature biomedical engineering2022

Prospective testing of clinical Cerenkov luminescence imaging against standard-of-care nuclear imaging for tumour location.

Edwin C Pratt, Magdalena Skubal, Benedict Mc Larney, Pamela Causa-Andrieu, Sudeep Das, Peter Sawan, Abdallah Araji, Christopher Riedl, Kunal Vyas, David Tuch and 1 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
  4. Review
  5. Observational
  6. Review
  7. Advanced Image-Guidance and Surgical-Navigation Techniques for Real-Time Visualized Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  8. Review
  9. Multiplexed imaging of radionuclides.Nature biomedical engineering · 2025
    Review
  10. Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  11. Optical (Cherenkov) dosimetry to unravel the radiobiological effects of radioisotope based therapy.European journal of nuclear medicine and molecular imaging · 2025
    Article
  12. Article
  13. Article
  14. Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging.European journal of nuclear medicine and molecular imaging · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Detection of Shortwave-Infrared Cerenkov Luminescence from Medical Isotopes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Edwin C PrattPharmacology Department, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0002-6054-6983
Magdalena Skubal *Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3446-5415
Benedict Mc Larney *Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pamela Causa-Andrieu *Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sudeep DasMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9393-204X
Peter SawanDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Abdallah ArajiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christopher RiedlDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kunal VyasLightpoint Medical Ltd., Waterside, Chesham, UK.ORCID http://orcid.org/0000-0002-9670-0233
David TuchLightpoint Medical Inc., Cambridge, MA, USA.
Jan GrimmPharmacology Department, Weill Cornell Medical College, New York, NY, USA. grimmj@mskcc.org.ORCID http://orcid.org/0000-0002-5282-9385
Memorial Sloan Kettering Cancer Center · USLightpoint Medical (United Kingdom) · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Cerenkov luminescence imaging for image-guided cancer surgeryR01CA183953 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2015 to 2019
$2.6M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA183953
6 · The paper itself

Abstract

In oncology, the feasibility of Cerenkov luminescence imaging (CLI) has been assessed by imaging superficial lymph nodes in a few patients undergoing diagnostic

Indexed as

Fluorodeoxyglucose F18NeoplasmsHumansLuminescenceLuminescent MeasurementsPositron-Emission TomographyPositron Emission Tomography Computed TomographyProspective StudiesFluorodeoxyglucose F18

Identifiers

PMID35411113
PMCPMC9149092
OpenAlexW4223484330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.