ArticleEye (London, England)2023
Retinal vein occlusion is associated with stroke independent of underlying cardiovascular disease.
Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Retinal ischemic perivascular lesions in cortical cerebral infarction: a comparison against controls.Eye (London, England) · 2026Article
- Association Between Retinal Vascular Occlusions and Stroke in Individuals With Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- Deep learning-derived retinal biomarker associated with diabetes-related amputation in type 2 diabetes.Frontiers in endocrinology · 2026Observational
- Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.Journal of cardiovascular development and disease · 2025Review
- Stroke subtypes risk prediction and detection using retinal vascular structure and oxygen saturation analysis.Quantitative imaging in medicine and surgery · 2025Article
- The Use of Retinal Imaging Including Fundoscopy, OCT, and OCTA for Cardiovascular Risk Stratification and the Detection of Subclinical Atherosclerosis.Current atherosclerosis reports · 2025Review
- Is retinal vein occlusion highly associated with an increased risk of myocardial infarction? A systematic review and meta-analysis.International journal of retina and vitreous · 2024Review
- Central retinal vein occlusion in patients with metastatic solid tumors on tyrosine kinase inhibitors: a report of case series and literature review.Frontiers in medicine · 2024Review
- [Internistic clarification of retinal vascular occlusions].Die Ophthalmologie · 2023Article
- Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques.Journal of personalized medicine · 2023Review
- A Datasheet for the INSIGHT University Hospitals Birmingham Retinal Vein Occlusion Data Set.Ophthalmology science · 2023Article
- Risk analysis for patients with arterial thromboembolic events after intravitreal ranibizumab or aflibercept injections.Scientific reports · 2023Article
- Impact of statin treatment on cardiovascular events in patients with retinal vein occlusion: a nested case-control study in Korea.Epidemiology and health · 2023Article
- Retinal Ischemic Perivascular Lesions, a Biomarker of Cardiovascular Disease.Ophthalmology. Retina · 2022Article
- Prevalence and factors associated with visual impairment in middle-aged and older Chinese population.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundStroke is a leading cause of mortality and morbidity. Thus, identifying associated risk factors may lead to earlier interventions aimed at reducing the risk of stroke development. Since cardiovascular disease simultaneously increases the risk of stroke and retinal vein occlusion (RVO), we sought to determine whether RVO is associated with the risk of stroke independent of underlying cardiovascular co-morbidities.
methodsIn this cross-sectional study, we reviewed the records of 80,754 individuals who were evaluated by an ophthalmologist over a 6-year period. We identified individuals with RVO, stroke and cardiovascular diseases including hypertension, diabetes mellitus, carotid disease, coronary artery disease and atrial fibrillation. Multivariable logistic regression models were used to analyze odds ratios for RVO and stroke.
resultsAfter adjusting for age, sex, cardiovascular disease and other risk factors, we found that the presence of RVO was associated with an odds ratio for stroke of 1.73 (CI, 1.40-2.12, p < 0.001). The association between RVO and stroke, after adjusting for sex and cardiovascular co-morbidities, was significantly stronger in individuals younger than 50 years of age, with an odds ratio of having a stroke of 3.06 (1.34-6.25, p < 0.001), while the presence of RVO in individuals older than 85 years was not significantly associated with stroke 1.19 (0.77-1.79, p = 0.41).
conclusionsOur findings demonstrate that RVO is significantly associated with stroke, even after adjusting for underlying cardiovascular co-morbidities. This association was highly significant in younger subjects, while not significant in older individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.