ArticleThe ISME journal2022
Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Phenotypic heterogeneity optimizes trade-offs during adaptive deployment of the type VI secretion system.PLoS biology · 2026Article
- Type VI-secretion system-mediated competition and virulence in clinical and environmentalMicrobiology spectrum · 2026Article
- Quorum sensing orchestrates parallel cell death pathways inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quorum sensing orchestrates parallel cell death pathways inbioRxiv : the preprint server for biology · 2024Article
- Article
- Emergence and genomic insights of non-pandemic O1Microbiology spectrum · 2023Article
- Community composition and the environment modulate the population dynamics of type VI secretion in human gut bacteria.Nature ecology & evolution · 2023Article
- Sporadic type VI secretion in seventh pandemicMicrobiology (Reading, England) · 2023Article
- Community composition and the environment modulate the population dynamics of type VI secretion in human gut bacteria.bioRxiv : the preprint server for biology · 2023Article
- PandemicLife science alliance · 2023Article
- Article
- Genome-Wide Association Study ofMicroorganisms · 2022Article
- Evolution of amBio · 2022Article
- The VarA-CsrA regulatory pathway influences cell shape in Vibrio cholerae.PLoS genetics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior is the type VI secretion system (T6SS). Interestingly and in contrast to non-pandemic or environmental isolates, the T6SS of the O1 El Tor clade of V. cholerae, which is responsible for the ongoing 7th cholera pandemic, is largely silent under standard laboratory culture conditions. Instead, these strains induce their full T6SS capacity only under specific conditions such as growth on chitinous surfaces (signaled through TfoX and QstR) or when the cells encounter low intracellular c-di-GMP levels (TfoY-driven). In this study, we identified a single nucleotide polymorphism (SNP) within an intergenic region of the major T6SS gene cluster of V. cholerae that determines the T6SS status of the cell. We show that SNP conversion is sufficient to induce T6SS production in numerous pandemic strains, while the converse approach renders non-pandemic/environmental V. cholerae strains T6SS-silent. We further demonstrate that SNP-dependent T6SS production occurs independently of the known T6SS regulators TfoX, QstR, and TfoY. Finally, we identify a putative promoter region adjacent to the identified SNP that is required for all forms of T6SS regulation in V. cholerae.
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