Evidence map›Paper›PMID 35411094›Full record

ArticleScientific reports2022

The ZZ domain of HERC2 is a receptor of arginylated substrates.

Adam H Tencer, Jiuyang Liu, Jing Zhu, Nathaniel T Burkholder, Yi Zhang, Wenwen Wu, Brian D Strahl, Tomohiko Ohta, Tatiana G Kutateladze

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Designing the Proteome with Chemical Tools: Degrons and Beyond.Chembiochem : a European journal of chemical biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Adam H Tencer *Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Jiuyang Liu *Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Jing ZhuDepartment of Translational Oncology, St. Marianna University Graduate School of Medicine, 2‑16‑1, Sugao, Miyamae‑ku, Kawasaki, 216‑8511, Japan.
Nathaniel T BurkholderDepartment of Biochemistry and Biophysics, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.
Yi ZhangDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Wenwen WuDepartment of Translational Oncology, St. Marianna University Graduate School of Medicine, 2‑16‑1, Sugao, Miyamae‑ku, Kawasaki, 216‑8511, Japan.
Brian D StrahlDepartment of Biochemistry and Biophysics, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.
Tomohiko OhtaDepartment of Translational Oncology, St. Marianna University Graduate School of Medicine, 2‑16‑1, Sugao, Miyamae‑ku, Kawasaki, 216‑8511, Japan.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. tatiana.kutateladze@cuanschutz.edu.
University of Colorado Denver · USSt. Marianna University School of Medicine · JPUniversity of North Carolina at Chapel Hill · US

Funding

Integrated Training in Cancer Model SystemsT32CA009156 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 1985 to 2020
$19.7M
Mechanisms of chromatin and transcriptional regulationR35GM126900 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian D Strahl · 2018 to 2026
$5.5M
Targeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1M
Molecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9M
The role of JADE in HBO complexesR01HL151334 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.8M
Epigenetic mechanisms for regulation of p300R01GM135671 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.4M
Interdomain crosstalk in MORC3R01GM125195 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2017 to 2021
$1.3M
Targeting acetylated histone H4 by MLL4R56AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2020
$512k
NCI NIH HHS CA252707NCI NIH HHS R01 CA252707NCI NIH HHS T32 CA009156NHLBI NIH HHS HL151334NHLBI NIH HHS R01 HL151334NIA NIH HHS R01 AG067664NIA NIH HHS R56 AG067664NIGMS NIH HHS GM125195NIGMS NIH HHS GM126900NIGMS NIH HHS R01 GM125195NIGMS NIH HHS R01 GM135671NIGMS NIH HHS R35 GM126900NIH HHS AG067664
6 · The paper itself

Abstract

The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2 (HERC2

Indexed as

UbiquitinUbiquitin-Protein LigasesBinding SitesHumansProteasome Endopeptidase ComplexProtein DomainsHERC2 protein, humanProteasome Endopeptidase ComplexUbiquitinUbiquitin-Protein Ligases

Identifiers

PMID35411094
PMCPMC9001736
OpenAlexW4223417160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.