ArticleTranslational psychiatry2022
Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders.Nature genetics · 2026Pooled it
- Making a case for using MDMA-assisted psychotherapy for borderline personality disorder and complex PTSD: a descriptive systematic review of the literature.Therapeutic advances in psychopharmacology · 2026Review
- Recommendations for research on psychiatric disorders, impulsivity and borderline personality in patients with polycystic ovary syndrome.Archives of women's mental health · 2025Article
- Manipulation and Instability: Exploring Machiavellianism and Borderline Personality Similarities and Differences.European journal of investigation in health, psychology and education · 2025Article
- The Association Between Borderline Personality Disorder Symptoms and Social Behaviour Among University Students.Medicina (Kaunas, Lithuania) · 2025Article
- Preschool Big Five Personality Traits Predict Childhood Peer Relationships and BPD but Not MDD in Late Adolescence.Personality and mental health · 2025Article
- Treating depression in patients with borderline personality disorder: clinical clues on the use of antidepressants.Annals of general psychiatry · 2024Review
- The association between borderline personality disorder, childhood trauma, neuroticism, and self-rated or clinician-rated functional impairment in euthymic bipolar disorder-1 patients.Frontiers in psychiatry · 2024Article
- Evidence for a shared genetic contribution to loneliness and borderline personality disorder.Translational psychiatry · 2023Article
- Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits.Molecular psychiatry · 2023Article
- Salivary testosterone and cortisol levels in borderline personality disorder before and after a 12-week group dialectical behavior therapy intervention.Frontiers in psychology · 2023Article
- MDMA-Assisted Psychotherapy for Borderline Personality Disorder.Focus (American Psychiatric Publishing) · 2022Review
Corrections and comments
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Authors and funding
30 authors at 12 institutions in 6 countries.
Funding
Abstract
Both environmental (e.g. interpersonal traumatization during childhood and adolescence) and genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/features in the general population indicate that genetic factors underlying these symptoms/features are shared in part with the personality traits of the Five Factor Model (FFM) of personality-the "Big Five". In the present study, the genetic overlap of BPD with the Big Five -Openness to Experience, Conscientiousness, Extraversion, Agreeableness, and Neuroticism- was assessed. Linkage disequilibrium score regression was used to calculate genetic correlations between a genome-wide association study (GWAS) in central European populations on BPD (N = 2543) and GWAS on the Big Five (N = 76,551-122,886, Neuroticism N = 390,278). Polygenic scores (PGS) were calculated to test the association of the genetic disposition for the personality traits with BPD case-control status. Significant positive genetic correlations of BPD were found with Neuroticism (rg = 0.34, p = 6.3*10
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