ArticleScientific reports2022
Clustering of Parkinson subtypes reveals strong influence of DRD2 polymorphism and gender.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Tailoring treatments: pharmacogenomics in the management of neurodegenerative diseases.Acta neurologica Belgica · 2026Review
- Whole exome sequencing identified six novel genes for depressive symptoms.Molecular psychiatry · 2025Article
- Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression.Addiction biology · 2023Article
- Parkinson's Disease Diagnosis Using Laplacian Score, Gaussian Process Regression and Self-Organizing Maps.Brain sciences · 2023Article
- Sex Differences in Parkinson's Disease: From Bench to Bedside.Brain sciences · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most classification approaches for idiopathic Parkinson's disease subtypes primarily focus on motor and non-motor symptoms. Besides these characteristics, other features, including gender or genetic polymorphism of dopamine receptors are potential factors influencing the disease's phenotype. By utilizing a kmeans-clustering algorithm we were able to identify three subgroups mainly characterized by gender, DRD2 Taq1A (rs1800497) polymorphism-associated with changes in dopamine signaling in the brain-and disease progression. A subsequent regression analysis of these subgroups further suggests an influence of their characteristics on the daily levodopa dosage, an indicator for medication response. These findings could promote further enhancements in individualized therapies for idiopathic Parkinson's disease.
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