Evidence map›Paper›PMID 35410933›Full record

ArticleBMJ open2022

Non-pharmacological therapies for postviral syndromes, including Long COVID: a systematic review and meta-analysis protocol.

Joht Singh Chandan, Kirsty Brown, Nikita Simms-Williams, Jenny Camaradou, Nasir Bashir, Dominic Heining, Olalekan Lee Aiyegbusi, Grace Turner, Samantha Cruz Rivera, Richard Hotham and 9 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
  2. Post-COVID Syndrome.Deutsches Arzteblatt international · 2023
    Pooled it
  3. Pooled it
  4. Bridging Gaps in Long COVID Therapy: A Review.Current medicinal chemistry · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Joht Singh ChandanInstitute of Applied Health Research, University of Birmingham, Birmingham, UK j.s.chandan.1@bham.ac.uk.ORCID 0000-0002-9561-5141
Kirsty BrownInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0001-9403-1593
Nikita Simms-WilliamsInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-4926-1995
Jenny CamaradouCOVID END Evidence Network, UK, UK.
Nasir BashirSchool of Dentistry, University of Birmingham, Birmingham, UK.
Dominic HeiningUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Olalekan Lee AiyegbusiInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0001-9122-8251
Grace TurnerInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-9783-9413
Samantha Cruz RiveraInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-1566-6804
Richard HothamInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Krishnarajah NirantharakumarInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Manoj SivanUniversity of Leeds, Leeds, UK.ORCID 0000-0002-0334-2968
Kamlesh KhuntiDepartment of Health Sciences, University of Leicester, Leicester, UK.ORCID 0000-0003-2343-7099
Devan RaindiSchool of Dentistry, University of Birmingham, Birmingham, UK.
Steven MarwahaInstitute for Mental Health, University of Birmingham, Birmingham, UK.
Sarah E HughesInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0001-5656-1198
Christel McMullanInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-0878-1513
Melanie CalvertInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-1856-837X
Shamil HaroonInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-0096-1413
University of Birmingham · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBHealth Data Research UK · GBNational Institute for Health Research · GBNIHR Research Delivery Network · GBUniversity of Leeds · GBUniversity of Leicester · GB

Funding

Medical Research Council MC_PC_20050
6 · The paper itself

Abstract

introductionPostviral syndromes (PVS) describe the sustained presence of symptoms following an acute viral infection, for months or even years. Exposure to the SARS-CoV-2 virus and subsequent development of COVID-19 has shown to have similar effects with individuals continuing to exhibit symptoms for greater than 12 weeks. The sustained presence of symptoms is variably referred to as 'post COVID-19 syndrome', 'post-COVID condition' or more commonly 'Long COVID'. Knowledge of the long-term health impacts and treatments for Long COVID are evolving. To minimise overlap with existing work in the field exploring treatments of Long COVID, we have only chosen to focus on non-pharmacological treatments.

aimsThis review aims to summarise the effectiveness of non-pharmacological treatments for PVS, including Long COVID. A secondary aim is to summarise the symptoms and health impacts associated with PVS in individuals recruited to treatment studies. METHODS AND ANALYSIS: Primary electronic searches will be performed in bibliographic databases including: Embase, MEDLINE, PyscINFO, CINAHL and MedRxiv from 1 January 2001 to 29 October 2021. At least two independent reviewers will screen each study for inclusion and data will be extracted from all eligible studies onto a data extraction form. The quality of all included studies will be assessed using Cochrane risk of bias tools and the Newcastle-Ottawa grading system. Non-pharmacological treatments for PVS and Long COVID will be narratively summarised and effect estimates will be pooled using random effects meta-analysis where there is sufficient methodological homogeneity. The symptoms and health impacts reported in the included studies on non-pharmacological interventions will be extracted and narratively reported. ETHICS AND DISSEMINATION: This systematic review does not require ethical approval. The findings from this study will be submitted for peer-reviewed publication, shared at conference presentations and disseminated to both clinical and patient groups. PROSPERO REGISTRATION NUMBER: The review will adhere to this protocol which has also been registered with PROSPERO (CRD42021282074).

Indexed as

COVID-19BiasHumansMeta-Analysis as TopicPost-Acute COVID-19 SyndromeResearch DesignSARS-CoV-2SyndromeSystematic Reviews as TopicCOVID-19INFECTIOUS DISEASESREHABILITATION MEDICINE

Identifiers

PMID35410933
PMCPMC9002258
OpenAlexW4223441647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.