ArticleNeurology2022
Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort.
Open access · hybridAbstract read
In one paragraph
Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review.The Journal of physiology · 2026Pooled it
- Physical activity and amyloid beta in middle-aged and older adults: A systematic review and meta-analysis.Journal of sport and health science · 2024Pooled it
- Persistent financial adversity and cognitive aging: a life course investigation.Innovation in aging · 2026Article
- Neurobiological correlates of longitudinal grey matter volume changes in preclinical Alzheimer's disease.medRxiv : the preprint server for health sciences · 2025Article
- Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging.Neurology · 2025Article
- Evaluation of plasma p-tau217 for detecting amyloid pathology in a heterogeneous community-based cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults.Brain : a journal of neurology · 2025Article
- Associations between night/shift working and late-life brain health.Brain communications · 2025Article
- Association of Brain and Ventricular Boundary Shift Integral Measurements with CSF Biomarkers: A Case-Control Study.Current Alzheimer research · 2025Article
- Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review.Genes · 2024Article
- Sex-Dependent Effects of Cardiometabolic Health andNeurology · 2024Article
- Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- From Mild Cognitive Impairment to Dementia: The Impact of Comorbid Conditions on Disease Conversion.Biomedicines · 2024Article
- Brain structure, amyloid, and behavioral features for predicting clinical progression in subjective cognitive decline.Human brain mapping · 2024Article
- Rates of cortical thinning in Alzheimer's disease signature regions associate with vascular burden but not with β-amyloid status in cognitively normal adults at age 70.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.Alzheimer's research & therapy · 2024Article
- Understanding the relationship between type-2 diabetes, MRI markers of neurodegeneration and small vessel disease, and dementia risk: a mediation analysis.European journal of epidemiology · 2024Article
- Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities.Alzheimer's research & therapy · 2024Article
- The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer's disease continuum participants.Alzheimer's research & therapy · 2024Article
- Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3.BMC neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 1 institution in 2 countries.
Sarah E KeussFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
William CoathFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Jennifer M NicholasFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Teresa PooleFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Josephine BarnesFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
David M CashFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Christopher A LaneFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Thomas D ParkerFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Ashvini KeshavanFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Sarah M BuchananFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Aaron Z WagenFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Mathew StoreyFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Matthew HarrisFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Ian B MaloneFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Carole H SudreFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Kirsty LuFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Sarah-Naomi JamesFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Rebecca StreetFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
David L ThomasFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
John C DicksonFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Heidi Murray-SmithFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Andrew WongFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Tamar FreibergerFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Sebastian CrutchFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Marcus RichardsFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Nick C FoxFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK.
Jonathan M SchottFrom the Dementia Research Centre (S.E.K., W.C., J.M.N., T.P., J.B., D.M.C., C.A.L., A.K. S.M.B., A.Z.W., M.S., M.H., I.B.M., C.H.S., K.L., R.S., H.M.-S, T.F., S.C., N.C.F., J.M.S.), Dementia Research Institute (D.M.C., N.C.F.), Leonard Wolfson Experimental Neurology Centre (D.L.T.), and Department of Brain Repair and Neurorehabilitation (D.L.T.), UCL Queen Square Institute of Neurology; Department of Medical Statistics (J.M.N., T.P.), London School of Hygiene and Tropical Medicine; 4. Department of Medicine (T.D.P.), Division of Brain Sciences, Imperial College London; MRC Unit for Lifelong Health and Ageing at UCL (C.H.S., S.-N.J., A.W., M.R.); Centre for Medical Image Computing (C.H.S.), University College London; School of Biomedical Engineering & Imaging Sciences (C.H.S.), King's College London; and Institute of Nuclear Medicine (J.C.D.), University College London Hospitals, UK. j.schott@ucl.ac.uk.
Norwegian Womens Public Health Association · NO
Funding
British Heart Foundation PG/17/90/33415Medical Research Council CSUB19166Medical Research Council MC_UU_00019/1Medical Research Council MC_UU_00019/2Medical Research Council MC_UU_00019/3Medical Research Council MC-UU-12019/1Medical Research Council MC_UU_12019/1Medical Research Council MC-UU-12019/3Medical Research Council MC_UU_12019/3Wellcome Trust 200109/Z/15/Z
Abstract
BACKGROUND AND
objectivesThe goals of this work were to quantify the independent and interactive associations of β-amyloid (Aβ) and white matter hyperintensity volume (WMHV), a marker of presumed cerebrovascular disease (CVD), with rates of neurodegeneration and to examine the contributions of
methodsParticipants underwent brain MRI and florbetapir-Aβ PET as part of Insight 46, an observational population-based study. Changes in whole-brain, ventricular, and hippocampal volume were directly measured from baseline and repeat volumetric T1 MRI with the boundary shift integral. Linear regression was used to test associations with baseline Aβ deposition, baseline WMHV,
resultsThree hundred forty-six cognitively normal participants (mean [SD] age at baseline scan 70.5 [0.6] years; 48% female) had high-quality T1 MRI data from both time points (mean [SD] scan interval 2.4 [0.2] years). Being Aβ positive at baseline was associated with 0.87-mL/y faster whole-brain atrophy (95% CI 0.03, 1.72), 0.39-mL/y greater ventricular expansion (95% CI 0.16, 0.64), and 0.016-mL/y faster hippocampal atrophy (95% CI 0.004, 0.027), while each 10-mL additional WMHV at baseline was associated with 1.07-mL/y faster whole-brain atrophy (95% CI 0.47, 1.67), 0.31-mL/y greater ventricular expansion (95% CI 0.13, 0.60), and 0.014-mL/y faster hippocampal atrophy (95% CI 0.006, 0.022). These contributions were independent, and there was no evidence that Aβ and WMHV interacted in their effects. There were no independent associations of DISCUSSION: Aβ and presumed CVD have distinct and additive effects on rates of neurodegeneration in cognitively normal elderly. These findings have implications for the use of MRI measures as biomarkers of neurodegeneration and emphasize the importance of risk management and early intervention targeting both pathways.
Indexed as
Alzheimer DiseaseCerebrovascular DisordersAgedAmyloid beta-PeptidesApolipoprotein E4AtrophyBirth CohortBrainFemaleHumansMagnetic Resonance ImagingMalePositron-Emission TomographyAmyloid beta-PeptidesApolipoprotein E4
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