ArticleNeurology2022
Connectomic Profiles and Cognitive Trajectories After Epilepsy Surgery in Children.
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Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
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6 citing papers in PubMed, 12 citations in OpenAlex.
- A deep representation learning model to predict response to vagus nerve stimulation.Nature communications · 2026Article
- Asymmetric Reinforcement Learning Explains Human Choice Patterns in Decision-making Under Risk.bioRxiv : the preprint server for biology · 2026Article
- The Eastern Association of Electroencephalographers: A Canadian/USA success story.Clinical neurophysiology practice · 2025Review
- Epilepsy surgery below the age of 5 years: Are we still in time to preserve developmental and intellectual functions?Epilepsia open · 2024Article
- Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline?Brain : a journal of neurology · 2024Article
- Examining cognition and brain networks using magnetoencephalography in paediatric autoimmune encephalitis and acute disseminated encephalomyelitis: a preliminary study.Brain communications · 2024Article
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Authors and funding
15 authors at 1 institution in 1 country.
Olivia N ArskiFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.ORCID 0000-0002-7597-9765
Daniel J MartireFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Julia M YoungFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Simeon M WongFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Hrishikesh SureshFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Elizabeth N KerrFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Ayako OchiFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Hiroshi OtsuboFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Roy SharmaFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Elysa WidjajaFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.ORCID 0000-0003-0986-5476
O Carter SneadFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.ORCID 0000-0001-8910-0478
Puneet JainFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.ORCID 0000-0002-6009-0859
Elizabeth J DonnerFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
Mary Lou SmithFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada.
George M IbrahimFrom the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical Science (O.N.A., G.M.I.), University of Toronto; Department of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University of Toronto; Institute of Biomaterials and Biomedical Engineering (S.M.W., G.M.I.), University of Toronto; Division of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, Department of Surgery, University of Toronto; Division of Neurology (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.), Hospital for Sick Children, University of Toronto; and Department of Psychology (M.L.S.), University of Toronto Mississauga, Ontario, Canada. george.ibrahim@sickkids.ca.
University of Toronto · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesNeurocognitive outcomes after surgery for temporal lobe epilepsy in childhood are variable. Postoperative changes are not directly predicted by seizure freedom, and associations between epilepsy, neuropsychological function, and developing neural networks are poorly understood. Here, we leveraged whole-brain connectomic profiling in magnetoencephalography (MEG) to retrospectively study associations between brain connectivity and neuropsychological function in children with temporal lobe epilepsy undergoing resective surgery.
methodsClinical and MEG data were retrospectively analyzed for children who underwent temporal lobe epilepsy surgery at the Hospital for Sick Children from 2000 to 2021. Resting-state connectomes were constructed from neuromagnetic oscillations via the weighted-phase lag index. Using a partial least-squares (PLS) approach, we assessed multidimensional associations between patient connectomes, neuropsychological scores, and clinical covariates. Bootstrap resampling statistics were performed to assess statistical significance.
resultsA total of 133 medical records were reviewed, and 5 PLS analyses were performed. Each PLS analysis probed a particular neuropsychological domain and the associations between its baseline and postoperative scores and the connectomic data. In each PLS analysis, a significant latent variable was identified, representing a specific percentage of the variance in the data and relating neural networks to clinical covariates, which included changes in rote verbal memory (n = 41, DISCUSSION: Here, we report that connectomes characterized by diffuse connectivity, reminiscent of developmentally immature networks, are associated with lower preoperative cognition and postoperative cognitive improvement. These findings provide a potential means to understand neurocognitive function in children with temporal lobe epilepsy and expected changes postoperatively.
Indexed as
ConnectomeEpilepsyEpilepsy, Temporal LobeChildCognitionHumansNeuropsychological TestsRetrospective Studies
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