Evidence map›Paper›PMID 35410769›Full record

Trial reportNeuromodulation : journal of the International Neuromodulation Society2023

Effects of Prefrontal Transcranial Direct Current Stimulation on Retention of Performance Gains on an Obstacle Negotiation Task in Older Adults.

Sudeshna A Chatterjee, Rachael D Seidler, Jared W Skinner, Paige E Lysne, Chanoan Sumonthee, Samuel S Wu, Ronald A Cohen, Dorian K Rose, Adam J Woods, David J Clark

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuromodulation : journal of the International Neuromodulation Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03122236 (Combining tDCS and Neurorehabilitation to Treat Age-related Deficits of Mobility and Cognition), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03122236 nacompletednot on this map

Combining tDCS and Neurorehabilitation to Treat Age-related Deficits of Mobility and Cognition: UPfront Walking Study

TypeinterventionalSponsorUniversity of FloridaRan2017 to 2021Enrolled20ConditionsMobility Limitation, Cognitive ImpairmentArmsNeurorehabilitation of Standard Walking, Neurorehabilitation of Complex Walking, Sham Transcranial Direct Current Stimulation (Sham tDCS), Active Transcranial Direct Current Stimulation (Active tDCS)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sudeshna A ChatterjeeDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, FL, USA. Electronic address: sudeshna1@ufl.edu.
Rachael D SeidlerDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Jared W SkinnerGeriatric Research, Education, and Clinical Center, Malcom Randall VA Medical Center, Gainesville, FL, USA.
Paige E LysneDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Chanoan SumontheeCollege of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Samuel S WuDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Ronald A CohenDepartment of Clinical and Health Psychology, Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Dorian K RoseBrain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, FL, USA; Department of Physical Therapy, University of Florida, Gainesville, FL, USA; Brooks Rehabilitation, Jacksonville, FL, USA.
Adam J WoodsDepartment of Clinical and Health Psychology, Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
David J ClarkDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, FL, USA.
University of Florida · USMalcom Randall VA Medical Center · US

Funding

Multimodal imaging of brain activity to investigate walking and mobility decline in older adultsU01AG061389 · NIA · UNIVERSITY OF FLORIDA · PI CLARK, DAVID J, MANINI, TODD · 2018 to 2023
$5.8M
Combining tDCS and neurorehabilitation to treat age-related deficits of mobility and cognitionR21AG053736 · NIA · UNIVERSITY OF FLORIDA · PI CLARK, DAVID J · 2017 to 2018
$407k
NIA NIH HHS R21 AG053736NIA NIH HHS U01 AG061389
6 · The paper itself

Abstract

objectivesComplex walking in older adults can be improved with task practice and might be further enhanced by pairing transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex. We tested the hypothesis that a single session of practice of a complex obstacle negotiation task paired with active tDCS in older adults would produce greater within-session improvements in walking performance and retention of gains, compared to sham tDCS and no tDCS conditions. MATERIALS AND

methodsA total of 50 older adults (mean age = 74.46 years ± 6.49) with self-reported walking difficulty were randomized to receive either active tDCS (active-tDCS group) or sham tDCS (sham-tDCS group) bilaterally to the dorsolateral prefrontal cortex or no tDCS (no-tDCS group). Each group performed ten practice trials of an obstacle negotiation task at their fastest safe speed. Retention of gains in walking performance was assessed with three trials conducted one week later. Within-session effects of practice and between-session retention effects on obstacle negotiation speed were examined.

resultsAt the practice session, all three groups exhibited significant within-session gains in walking speed (p ≤ 0.005). However, the gains were significantly greater in the sham-tDCS group than in the active-tDCS and no-tDCS groups (p ≤ 0.03) and were comparable between the active-tDCS and no-tDCS groups (p = 0.89). At one-week follow-up, the active-tDCS group exhibited significant between-session retention of gains and continued "offline" improvement in walking speed (p = 0.005). The active-tDCS group showed significantly greater retention of gains than the no-tDCS (p = 0.02) but not the sham-tDCS group (p = 0.24).

conclusionsPairing prefrontal active tDCS with a single session of obstacle negotiation practice may enhance one-week retention of gains in walking performance compared to no tDCS. However, the evidence is insufficient to suggest a benefit of active tDCS over sham tDCS for enhancing the gains in walking performance. Additional studies with a multisession intervention design and larger sample size are needed to further investigate these findings. CLINICAL

trial registrationThe Clinicaltrials.gov registration number for the study is NCT03122236.

Indexed as

Transcranial Direct Current StimulationAgedDouble-Blind MethodHumansNegotiatingPrefrontal CortexWalkingAgingprefrontal cortexrehabilitationtranscranial direct current stimulationwalking

Identifiers

PMID35410769
PMCPMC9547038
OpenAlexW4223415712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.