Evidence map›Paper›PMID 35410714›Full record

ReviewSeminars in perinatology2022

Neuroimaging of structural and functional connectivity in preterm infants with intraventricular hemorrhage.

Regina L Triplett, Christopher D Smyser

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in perinatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Regina L TriplettDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Christopher D SmyserDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: smyserc@wustl.edu.
Washington University in St. Louis · US

Funding

Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental DisordersR01MH113883 · NIMH · WASHINGTON UNIVERSITY · PI JOAN L. LUBY, Christopher Daniel Smyser · 2018 to 2026
$20.6M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY, Natasha Marrus · 2020 to 2026
$15.5M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Trajectories of Cortico-Cerebellar Connectivity, Social Competence, and Internalizing Symptoms in Adolescents Born Very PretermR37MH113570 · NIMH · WASHINGTON UNIVERSITY · PI CYNTHIA Elise ROGERS, Christopher Daniel Smyser · 2022 to 2026
$3.8M
THE PRETERM BEHAVIORAL PHENOTYPE: TRAJECTORIES OF PSYCHOPATHOLOGY & CHANGES IN CEREBRAL CONNECTIVITYR01MH113570 · NIMH · WASHINGTON UNIVERSITY · PI ROGERS, CYNTHIA ELISE, SMYSER, CHRISTOPHER DANIEL · 2017 to 2021
$3.1M
Effects of ventricular volume and cerebral connectivity on neurological outcomes in preterm intraventricular hemorrhageR01NS124767 · NINDS · WASHINGTON UNIVERSITY · PI David Delmar Limbrick, Christopher Daniel Smyser · 2022 to 2026
$3.0M
PREDICTING CHILDHOOD OUTCOMES IN PRETERM INFANTS USING CEREBRAL CONNECTIVITYK02NS089852 · NINDS · WASHINGTON UNIVERSITY · PI SMYSER, CHRISTOPHER DANIEL · 2014 to 2018
$848k
NICHD NIH HHS P50 HD103525NIMH NIH HHS R01 MH113570NIMH NIH HHS R01 MH113883NIMH NIH HHS R37 MH113570NIMH NIH HHS T32 MH100019NINDS NIH HHS K02 NS089852NINDS NIH HHS R01 NS124767
6 · The paper itself

Abstract

Preterm infants with intraventricular hemorrhage (IVH) are known to have some of the worst neurodevelopmental outcomes in all of neonatal medicine, with a growing body of evidence relating these outcomes to underlying disruptions in brain structure and function. This review begins by summarizing state-of-the-art neuroimaging techniques delineating structural and functional connectivity (diffusion and resting state functional MRI) and their application in infants with IVH, including unique technical challenges and emerging methods. We then review studies of altered structural and functional connectivity, highlighting the role of IVH severity and location. We subsequently detail investigations linking structural and functional findings in infancy to later outcomes in early childhood. We conclude with future directions including methodologic considerations for prospective and potentially interventional studies designed to mitigate disruptions to underlying structural and functional connections and improve neurodevelopmental outcomes in this high-risk population.

Indexed as

Infant, PrematureInfant, Premature, DiseasesCerebral HemorrhageChild, PreschoolHumansInfantInfant, NewbornNeuroimagingProspective Studiesdiffusion tensor imaging (DTI)functional connectivityintraventricular hemorrhage (IVH)magnetic resonance imaging (MRI)neurodevelopmentpost-hemorrhagic hydrocephalusresting state functional MRI (rs-fMRI)very preterm infant

Identifiers

PMID35410714
PMCPMC9910034
OpenAlexW4220872905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.