Evidence map›Paper›PMID 35410518›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Genetic ablation of smooth muscle K

Paulina M Kowalewska, Jacob Fletcher, William F Jackson, Suzanne E Brett, Michelle Sm Kim, Galina Yu Mironova, Nadia Haghbin, David M Richter, Nathan R Tykocki, Mark T Nelson and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  5. Article
  6. KMicrocirculation (New York, N.Y. : 1994) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Paulina M KowalewskaRobarts Research Institute and the Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.ORCID 0000-0003-3231-3020
Jacob FletcherRobarts Research Institute and the Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.
William F JacksonDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Suzanne E BrettRobarts Research Institute and the Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.
Michelle Sm KimRobarts Research Institute and the Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.
Galina Yu MironovaRobarts Research Institute and the Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.
Nadia HaghbinRobarts Research Institute and the Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.
David M RichterRobarts Research Institute and the Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.
Nathan R TykockiDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0001-5432-7656
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Donald G WelshRobarts Research Institute and the Department of Physiology & Pharmacology, University of Western Ontario, London, ON, Canada.
Western University · CAMichigan State University · USUniversity of Vermont · US

Funding

SIGNALING MECHANISMS IN ARTERIES AND VEINS IN HYPERTENSIONP01HL070687 · NHLBI · MICHIGAN STATE UNIVERSITY · PI WATTS, STEPHANIE W · 2003 to 2019
$22.8M
Cerebral parenchymal arteriole dysfunction and cognitive decline in a life-long high fat feeding modelR01HL137694 · NHLBI · MICHIGAN STATE UNIVERSITY · PI DORRANCE, ANNE M., JACKSON, WILLIAM F. · 2017 to 2020
$2.1M
TRPV1 Mediates Progressive Stress-Induced Bladder DysfunctionR01DK119615 · NIDDK · MICHIGAN STATE UNIVERSITY · PI MINGIN, GERALD, TYKOCKI, NATHAN ROGER · 2019 to 2023
$1.9M
Bladder Blood Flow and Vascular Contractility Regulate Bladder FunctionK01DK103840 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TYKOCKI, NATHAN ROGER · 2015 to 2019
$754k
CIHR RN35401NHLBI NIH HHS P01 HL070687NHLBI NIH HHS R01 HL137694NIDDK NIH HHS K01 DK103840NIDDK NIH HHS R01 DK119615
6 · The paper itself

Abstract

Cerebral blood flow is a finely tuned process dependent on coordinated changes in arterial tone. These changes are strongly tied to smooth muscle membrane potential and inwardly rectifying K

Indexed as

Potassium Channels, Inwardly RectifyingAnimalsCerebral ArteriesMiceMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MusclePotassium Channels, Inwardly RectifyingArterial spin-labeling MRIcerebral blood flowelectrophysiologymyographypotassium channels

Identifiers

PMID35410518
PMCPMC9441723
OpenAlexW4223415304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.