ArticleActa neuropathologica communications2022
Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change.
Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature.Acta neuropathologica communications · 2022Pooled it
- Cortical subpial aging-related tau astrogliopathy in older adult men who participated in youth amateur American-style football.Journal of neuropathology and experimental neurology · 2026Article
- Performance of traumatic encephalopathy syndrome criteria in identifying individuals with chronic traumatic encephalopathy.Nature medicine · 2026Article
- Chronic traumatic encephalopathy neuropathologic change is associated with highest stage limbic-predominant age-related TDP-43 encephalopathy.Journal of neuropathology and experimental neurology · 2026Article
- Traumatic brain injury or head impacts from contact sports are associated with tau astrogliopathy.Brain : a journal of neurology · 2025Article
- Nandrolone Abuse Prior to Head Trauma Mitigates Endoplasmic Reticulum Stress, Mitochondrial Bioenergetic Deficits, and Markers of Neurodegeneration.Molecular neurobiology · 2025Article
- The prevalence of chronic traumatic encephalopathy in a historical epilepsy post-mortem collection.Brain pathology (Zurich, Switzerland) · 2025Article
- Epidemiological Principles in Claims of Causality: An Enquiry into Repetitive Head Impacts (RHI) and Chronic Traumatic Encephalopathy (CTE).Sports medicine (Auckland, N.Z.) · 2025Review
- Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.Acta neuropathologica · 2024Article
- Chronic traumatic encephalopathy pathognomonic lesions occurring in isolation adjacent to infiltrative and non-infiltrative white matter lesions.Journal of neuropathology and experimental neurology · 2024Article
- Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy.Journal of neuroinflammation · 2024Article
- Chronic traumatic encephalopathy and aging-related tau astrogliopathy in community-dwelling older persons with and without moderate-to-severe traumatic brain injury.Journal of neuropathology and experimental neurology · 2024Article
- Brain pathology and symptoms linked to concussion history: beyond chronic traumatic encephalopathy.Brain communications · 2024Article
- The neuropathology of intimate partner violence.Acta neuropathologica · 2023Article
- Chronic traumatic encephalopathy-neuropathologic change in a routine neuropathology service: 7-year follow-up.Journal of neuropathology and experimental neurology · 2023Article
- Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts.Acta neuropathologica · 2023Review
- Neurotrauma: 2023 Update.Free neuropathology · 2023Article
- Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football.Frontiers in neurology · 2023Article
- Tau Pathology in Chronic Traumatic Encephalopathy is Primarily Neuronal.Journal of neuropathology and experimental neurology · 2022Article
- Applying the Bradford Hill Criteria for Causation to Repetitive Head Impacts and Chronic Traumatic Encephalopathy.Frontiers in neurology · 2022Review
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Authors and funding
16 authors at 18 institutions in 3 countries.
Funding
Abstract
Traumatic brain injury (TBI) is associated with the development of a range of neurodegenerative pathologies, including chronic traumatic encephalopathy (CTE). Current consensus diagnostic criteria define the pathognomonic cortical lesion of CTE neuropathologic change (CTE-NC) as a patchy deposition of hyperphosphorylated tau in neurons, with or without glial tau in thorn-shaped astrocytes, typically towards the depths of sulci and clustered around small blood vessels. Nevertheless, although incorporated into consensus diagnostic criteria, the contribution of the individual cellular components to identification of CTE-NC has not been formally evaluated. To address this, from the Glasgow TBI Archive, cortical tissue blocks were selected from consecutive brain donations from contact sports athletes in which there was known to be either CTE-NC (n = 12) or Alzheimer's disease neuropathologic change (n = 4). From these tissue blocks, adjacent tissue sections were stained for tau antibodies selected to reveal either solely neuronal pathology (3R tau; GT-38) or mixed neuronal and astroglial pathologies (4R tau; PHF-1). These stained sections were then randomised and independently assessed by a panel of expert neuropathologists, blind to patient clinical history and primary antibody applied to each section, who were asked to record whether CTE-NC was present. Results demonstrate that, in sections stained for either 4R tau or PHF-1, consensus recognition of CTE-NC was high. In contrast, recognition of CTE-NC in sections stained for 3R tau or GT-38 was poor; in the former no better than chance. Our observations demonstrate that the presence of both neuronal and astroglial tau pathologies facilitates detection of CTE-NC, with its detection less consistent when neuronal tau pathology alone is visible. The combination of both glial and neuronal pathologies, therefore, may be required for detection of CTE-NC.
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