Evidence map›Paper›PMID 35410323›Full record

ArticleNPJ vaccines2022

Elimination of receptor binding by influenza hemagglutinin improves vaccine-induced immunity.

Hilary E Hendin, Pierre-Olivier Lavoie, Jason M Gravett, Stéphane Pillet, Pooja Saxena, Nathalie Landry, Marc-André D'Aoust, Brian J Ward

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Stabilized mosaic hemagglutinin immunogens as novel universal influenza virus vaccines.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hilary E HendinDepartment of Microbiology and Immunology, McGill University, 3775 University Street, Montréal, QC, H3A 2B4, Canada.ORCID http://orcid.org/0000-0002-0205-5692
Pierre-Olivier LavoieMedicago Inc., 1020 Route de l'Église, Bureau 600, Québec, QC, Canada.
Jason M GravettDepartment of Microbiology and Immunology, McGill University, 3775 University Street, Montréal, QC, H3A 2B4, Canada.
Stéphane PilletResearch Institute of McGill University Health Centre, Glen Site, 1001 Décarie Boul., Montréal, QC, H4AG 3J1, Canada.
Pooja SaxenaMedicago Inc., 1020 Route de l'Église, Bureau 600, Québec, QC, Canada.
Nathalie LandryMedicago Inc., 1020 Route de l'Église, Bureau 600, Québec, QC, Canada.
Marc-André D'AoustMedicago Inc., 1020 Route de l'Église, Bureau 600, Québec, QC, Canada. daoustma@medicago.com.
Brian J WardResearch Institute of McGill University Health Centre, Glen Site, 1001 Décarie Boul., Montréal, QC, H4AG 3J1, Canada. brian.ward@mcgill.ca.ORCID http://orcid.org/0000-0003-3251-958X
McGill University Health Centre · CAMedicago (Canada) · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The binding of influenza hemagglutinin (HA) to sialic acid (SA) receptors plays a well-defined role in shaping infection but the impact of such binding on vaccine responses has not yet been explored. We generated a virus-like particle (VLP) vaccine bearing the HA of H1N1 A/California/07/09 that is unable to bind to its α(2,6)-linked SA receptor (H1

Identifiers

PMID35410323
PMCPMC9001741
OpenAlexW4223475576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.