Evidence map›Paper›PMID 35410320›Full record

ArticleCell death & disease2022

Evolution of gene expression signature in mammary gland stem cells from neonatal to old mice.

Xiaoling Huang, Yue Xu, Lu Qian, Qian Zhao, Pengfei Liu, Jinhui Lü, Yuefan Guo, Wenjing Ma, Guangxue Wang, Shujun Li and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Xiaoling Huang *Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Yue Xu *Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Lu Qian *Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Qian ZhaoResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Pengfei LiuResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Jinhui LüResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Yuefan GuoResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Wenjing MaResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Guangxue WangResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Shujun LiResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
An LuoResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China.
Xiaolai YangDepartment of Pharmacy, The People's Hospital of Gansu Province, Lanzhou, China. yxl1668@vip.163.com.
Haiyun WangResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China. wanghaiyun@tongji.edu.cn.ORCID 0000-0001-8364-8328
Zuoren YuResearch Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, School of Medicine, Tongji University, Shanghai, 200120, China. Zuoren.yu@tongji.edu.cn.ORCID 0000-0003-4196-9662
Shanghai East Hospital · CNTongji University · CNGansu Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the lifetime of females, mammary epithelial cells undergo cyclical expansion and proliferation depending on the cyclical activation of mammary gland stem/progenitor cells (MaSCs) in response to the change of hormone level. The structural shrink of mammary duct tree and the functional loss of mammary gland occur along with inactivation of MaSCs in old females, even leading to breast cancer occasionally. However, the gene expression signature in MaSCs across the lifespan remains unclear. Herein, we tested the tissue regeneration ability of CD24

Indexed as

Mammary Glands, AnimalTranscriptomeAnimalsCell Transformation, NeoplasticEpithelial CellsFemaleMiceStem Cells

Identifiers

PMID35410320
PMCPMC9001724
OpenAlexW4223479544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.