Evidence map›Paper›PMID 35410314›Full record

ReviewMilitary Medical Research2022

Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury.

Yan Wang, Hong-Qian Lv, Xuan Chao, Wen-Xin Xu, Yun Liu, Gui-Xia Ling, Peng Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Military Medical Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  17. Neuroprotective role of DNTαβ Cell transplantation on modulating immune microenvironment in spinal cord injured mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan WangShenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
Hong-Qian LvShenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
Xuan ChaoShenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
Wen-Xin XuShenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
Yun LiuCenter for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Gui-Xia LingShenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China. pharlab@163.com.
Peng ZhangShenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China. zhangpenglab@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, which can give rise to the loss of motor and sensory function. Due to its complex pathological mechanism, the treatment of this disease still faces a huge challenge. Hydrogels with good biocompatibility and biodegradability can well imitate the extracellular matrix in the microenvironment of spinal cord. Hydrogels have been regarded as promising SCI repair material in recent years and continuous studies have confirmed that hydrogel-based therapy can effectively eliminate inflammation and promote spinal cord repair and regeneration to improve SCI. In this review, hydrogel-based multimodal therapeutic strategies to repair SCI are provided, and a combination of hydrogel scaffolds and other therapeutic modalities are discussed, with particular emphasis on the repair mechanism of SCI.

Indexed as

HydrogelsSpinal Cord InjuriesHumansHydrogelsHydrogel scaffoldsInjectable hydrogelsMultimodal therapySpinal cord injury

Identifiers

PMID35410314
PMCPMC9003987

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.