SynthesisBMC cancer2022
The oncological safety of autologous fat grafting: a systematic review and meta-analysis.
Synthesis in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Efficacy of Exclusive Fat Grafting for Breast Reconstruction: An Updated Systematic Review and Meta-analysis.Aesthetic plastic surgery · 2024Pooled it
- Autologous Fat Grafting for Functional and Aesthetic Improvement in Patients with Head and Neck Cancer: A Systematic Review.Aesthetic plastic surgery · 2023Pooled it
- Mammary adipocyte plasticity and epithelial crosstalk: roles in development, remodeling, and disease.Reviews in endocrine & metabolic disorders · 2026Review
- Seven Years of Complaints from Patients in Plastic Surgery Hospitals About Autologous Fat Transfer Procedures.Aesthetic plastic surgery · 2026Article
- Outcomes and Complications of Autologous Fat Transfer for Total Breast Reconstruction and Augmentation: Systematic Review and Meta-analysis of Randomized Controlled Trials.Plastic and reconstructive surgery. Global open · 2026Article
- Autologous fat grafting and injectable fillers for post-reconstructive breast remodelling: A systematic review and quantitative synthesis.JPRAS open · 2026Review
- Feasibility and aesthetic outcomes of immediate fat-augmented latissimus dorsi (FALD) flap reconstruction post-mastectomy: a prospective cohort study from a tertiary breast centre.Gland surgery · 2026Article
- Sialocele following excision of delayed-onset inflamed facial fat graft: A case report.Medicine · 2026Article
- Stemness and clinical performance of water-jet technology: A translational study in breast reconstruction.JPRAS open · 2025Article
- Optimal Recipient Nerve Selection for Breast Neurotization with Abdominal Flaps: A Comprehensive Meta-Analysis of Anterior and Lateral Intercostal Approaches.Journal of clinical medicine · 2025Review
- The Role of Exclusive Autologous Lipotransfer in Non-Irradiated Breasts After Mastectomy.Journal of clinical medicine · 2025Review
- Radiologic findings in women after Autologous Fat Transfer (AFT) based breast reconstruction: A Systematic Review.JPRAS open · 2024Review
- Breast Lipofilling: Is the Bra Really Full? Clinical Bra Pressure Measurement and In Vitro Testing of Processed and Unprocessed Fat Cells.Aesthetic plastic surgery · 2024Article
- Clinical outcomes of breast reconstruction using omental flaps: A systematic review.JPRAS open · 2024Review
- Imaging findings after a total reconstructed breast with autologous fat transfer: what the radiologist needs to know.BJR open · 2024Review
- Augmentation-Mastopexy With 4-Layer Autologous Fat Grafting and Evaluation of Viability With MRI.Aesthetic surgery journal. Open forum · 2024Article
- Adipose mesenchymal stem cell conditioned medium and extract: A promising therapeutic option for regenerative breast cancer therapy.SAGE open medicine · 2024Article
- Investigation of symptom management and functional state of women who underwent breast cancer surgery.Revista da Associacao Medica Brasileira (1992) · 2024Article
- An In Vitro Approach for Investigating the Safety of Lipotransfer after Breast-Conserving Therapy.Journal of personalized medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo present a systematic review of the literature and a meta-analysis evaluating the oncological safety of autologous fat grafting (AFG). SUMMARY BACKGROUND DATA: AFG for breast reconstruction presents difficulties during follow-up radiological exams, and the oncological potential of grafted fat is uncertain. Previous studies confirmed that the fatty tissue could be transferred under a good condition suitable would not interfere with mammographic follow-up, although the issue of oncological safety remains.
methodsWe reviewed the literature published until 01/18/2021. The outcomes were overall survival (OS), disease-free survival (DFS), and local recurrence (LR). We included studies that evaluated women with breast cancer who undergone surgery followed by reconstruction with AFG. We synthesized data using the inverse variance method on the log-HR (log of the hazard ratio) scale for time-to-event outcomes using RevMan. We assessed heterogeneity using the Chi
resultsFifteen studies evaluating 8541 participants were included. The hazard ratios (HR) could be extracted from four studies, and there was no difference in OS between the AFG group and control (HR 0.9, 95% CI 0.53 to 1.54, p = 0.71, I
conclusionAccording to the current evidence, AFG is a safe technique of breast reconstruction for patients that have undergone BC surgery and did not affect OS, DFS, or LR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.