ReviewInternational journal of environmental research and public health2022
Genotoxic Effects of Lead and Their Impact on the Expression of DNA Repair Genes.
Review in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Combined Occupational Exposure to Lead and Other Metals and Risk of Lung Cancer.La Medicina del lavoro · 2026Article
- Lead (Pb) bioremediation by Sphingobium sp. RO-01 strain isolated from gold mine tailings, Atacama Desert, Chile.World journal of microbiology & biotechnology · 2026Article
- Impact of OGG1 and PARP1 Variants on Lead and Cadmium Induced DNA Damage in Metal Handicraft Workers of Jodhpur.Biological trace element research · 2026Article
- Lead Exposure Triggers DNA Damage in TK6 Cells Via Alteration of DNA Repair Gene Expression and Hypermethylation of Ku80 Promoter Region.Biological trace element research · 2026Article
- Article
- Toward Smart Salivary Diagnostics: A Comprehensive Review of Heavy Metal Biomarkers and Digital Risk Modeling.Diagnostics (Basel, Switzerland) · 2026Review
- Artemisia and the Elements: A Botanical Symphony of Minerals and Metals.Biological trace element research · 2026Review
- Neuroprotective Potential ofInternational journal of molecular sciences · 2026Article
- Lead and cadmium levels in blood among painters and battery workers: A case control study.Bioinformation · 2026Article
- Disturbances in Mitochondrial Network, Biogenesis, and Mitochondria-Mediated Inflammatory Responses in Selected Brain Structures of Rats Exposed to Lead (Pb) During Prenatal and Neonatal Development.International journal of molecular sciences · 2025Article
- A Narrative Review of Metallomic Studies: Revealing the Toxic Metal Burden in Tobacco Smokers.International journal of molecular sciences · 2025Review
- Heavy Metal-Contaminated Soils and Gastric Cancer Risk: Molecular Insights and the Relevance of a One Health Perspective.International journal of molecular sciences · 2025Review
- Perinatal Lead (Pb) Exposure Increases Mouse Embryonic Weight and Alters Neuronal Gene Expression.bioRxiv : the preprint server for biology · 2025Article
- The Mechanisms of Lead Toxicity in Living Organisms.Journal of xenobiotics · 2025Review
- Review
- Effect of Lead Exposure and Lifestyle Factors on Methylation Index Markers Among Pb-Exposed Workers.Biological trace element research · 2025Article
- Paternal Lead Exposure and Pregnancy Outcomes: A Systematic Review and Meta-Analysis.Environmental health insights · 2025Review
- Elucidation of Potential Genotoxicity of MXenes Using a DNA Comet Assay.ACS applied bio materials · 2024Article
- Phenolic Compounds from Tropea Red Onion as Dietary Agents for Protection against Heavy Metals Toxicity.Life (Basel, Switzerland) · 2024Article
- Research progress in the detection of trace heavy metal ions in food samples.Frontiers in chemistry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to lead (Pb) continues to be a significant worldwide problem. Pb is a highly poisonous heavy metal affecting several organ systems in the body. Although Pb has been shown to be genotoxic to experimental animals and humans, the underlying mechanisms are still not understood. An indirect mechanism related to the inhibition of DNA repair systems by Pb has been suggested. Heavy metals can interfere with the activities of several proteins and gene expressions. Recent studies gathered in this review article demonstrated an altered expression of DNA repair genes due to Pb toxicity. However, their findings are conflicting. Furthermore, the interaction of Pb and epigenetic mechanisms regulating gene expression may have a crucial role in the inhibition of DNA repair systems. Therefore, additional studies are needed to evaluate these findings and to obtain a complete picture of the genotoxic properties of Pb and the underlying mechanisms that may have a crucial role in carcinogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.