Evidence map›Paper›PMID 35409924›Full record

ArticleInternational journal of environmental research and public health2022

Neurological and Mental Health Symptoms Associated with Post-COVID-19 Disability in a Sample of Patients Discharged from a COVID-19 Ward: A Secondary Analysis.

Martina Cacciatore, Alberto Raggi, Andrea Pilotto, Viviana Cristillo, Erika Guastafierro, Claudia Toppo, Francesca G Magnani, Davide Sattin, Arianna Mariniello, Fabiola Silvaggi and 9 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  6. How do fatigue, cognitive dysfunction, activity and role functioning, and mental health inter-relate in adults with post-COVID-19 syndrome? A structural equation model analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Martina CacciatoreNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0002-3379-6725
Alberto RaggiNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0002-7433-7779
Andrea PilottoNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.
Viviana CristilloNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.
Erika GuastafierroNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Claudia ToppoNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Francesca G MagnaniNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0002-6503-3052
Davide SattinNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Arianna MarinielloNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Fabiola SilvaggiNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0003-3745-632X
Stefano Cotti PiccinelliNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.
Nicola ZoppiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-6594-0517
Giulio BonziNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.
Stefano GipponiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.
Ilenia LibriNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.
Michela BezziRespiratory Unit, ASST Spedali Civili di Brescia, 25121 Brescia, Italy.ORCID 0000-0001-8200-4336
Paolo MartellettiDepartment of Clinical and Molecular Medicine, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-6556-4128
Matilde LeonardiNeurology, Public Health Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.ORCID 0000-0003-0552-8923
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITUniversity of Brescia · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITCTO Andrea Alesini · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies suggest that COVID-19 survivors may experience long-term health consequences: in particular, neurological and mental health symptoms might be associated with long-term negative outcomes. This study is a secondary analysis of a larger cohort study and aims to determine the extent to which neurological and mental health sequelae are associated with survivors' disability. Participants include COVID-19 survivors, with no pre-morbid brain conditions, who were discharged from the COVID-19 Unit of the ASST Spedali Civili Hospital between February and April 2020. At an average of 3.5 months after discharge, they were submitted to a neurological examination and completed the WHO Disability Assessment Schedule (WHODAS-12), the Hospital Anxiety and Depression Score, the Pittsburgh Sleep Quality Index and the Montreal Cognitive Assessment. Multivariable regression analysis was carried out to analyze variables that explain WHODAS-12 variation. In total, 83 patients (63 males, average age 66.9, 95% CI: 64.2-69.7) were enrolled; average WHODAS-12 was 13.2 (95% CI: 9.7-16.6). Cognitive dysfunction, anxiety, fatigue, and hyposmia/hypogeusia explained 28.8% of WHODAS-12 variation. These findings underline the importance and need for longitudinal follow-up assessments after recovery from COVID-19 and suggest the need for early rehabilitation of residual symptoms to enhance patients' functioning.

Indexed as

COVID-19Mental HealthAgedAnxietyCohort StudiesHospitalsHumansMaleanxietybrain impairmentcognitive dysfunctionCOVID-19disabilityfatiguehypogeusiahyposmiaWHODAS-12

Identifiers

PMID35409924
PMCPMC8998950
OpenAlexW4223494310

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.