ArticleInternational journal of environmental research and public health2022
Transcending the Male-Female Binary in Biomedical Research: Constellations, Heterogeneity, and Mechanism When Considering Sex and Gender.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gender in suicide prevention in adolescents and young adults: a systematic review.BMC public health · 2026Pooled it
- Twenty years of sex and gender science in health research: a policy statement from the Organization for the Study of Sex Differences.Biology of sex differences · 2026Review
- Diversity-in-a-dish: A practical framework for hiPSC model development.Stem cell reports · 2026Review
- Sex and gender influences on problematic cannabis use and cannabis use disorder: A scoping review protocol.PloS one · 2026Article
- Sex differences in the acute effects of cannabis: the need for hypothesis-driven research.Journal of psychiatry & neuroscience : JPN · 2026Article
- Reframing the sex debate in scientific research: three frameworks to support rigor without rigidity.Biology of sex differences · 2025Article
- Limitations of the Male/Female Binary for Studying the Influences of Sex- and Gender-Related Factors on Health.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Tailoring Treatment: The Role of Sex/Gender-Specific Medicine.The world journal of men's health · 2025Article
- Intersectional analysis for science and technology.Nature · 2025Review
- Article
- Review
- Health systems and quality of healthcare: bringing back missing discussions about gender and sexuality.Health systems (Basingstoke, England) · 2024Article
- Interrogating global narratives of trans queerness. Well-being and agency? Or more stories of trans trauma?Frontiers in sociology · 2024Review
- Tailoring Rheumatoid Arthritis Treatment through a Sex and Gender Lens.Journal of clinical medicine · 2023Review
- Best practices to promote rigor and reproducibility in the era of sex-inclusive research.eLife · 2023Article
- Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes.Biology of sex differences · 2023Article
- Impacts of recreational cannabis legalization on use and harms: A narrative review of sex/gender differences.Frontiers in psychiatry · 2023Review
- Operationalization of a multidimensional sex/gender concept for quantitative environmental health research and implementation in the KORA study: Results of the collaborative research project INGER.Frontiers in public health · 2023Article
- How Can Quantitative Analysis Be Used to Improve Occupational Health without Reinforcing Social Inequalities? An Examination of Statistical Methods.International journal of environmental research and public health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accounting for the influences of sex- and gender-related factors on health is one of the most interesting and important challenges in contemporary health research. In biomedical research, models, experimental designs, and statistical analyses create particular challenges in attempting to incorporate the complex, dynamic, and context-dependent constructs of sex and gender. Here, we offer conceptual elaborations of the constructs of sex and gender and discuss their application in biomedical research, including a more mechanism-oriented and context-driven approach to experimental design integrating sex and gender. We highlight how practices of data visualization, statistical analysis, and rhetoric can be valuable tools in expanding the operationalization of sex and gender biomedical science and reducing reliance on a male-female binary approach.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.