Evidence map›Paper›PMID 35409689›Full record

ArticleInternational journal of environmental research and public health2022

Peripheral Iron Levels in Autism Spectrum Disorders vs. Other Neurodevelopmental Disorders: Preliminary Data.

Andrea De Giacomo, Silvia Medicamento, Chiara Pedaci, Donatella Giambersio, Orazio Valerio Giannico, Maria Giuseppina Petruzzelli, Marta Simone, Massimo Corsalini, Lucia Marzulli, Emilia Matera

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Iron dysregulation in the central nervous system: implications for autism spectrum disorder.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Restless sleep disorder in a sample of children and adolescents with autism spectrum disorder: preliminary results from a case series.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  7. Is iron depletion the only cause of motor restlessness in restless sleep presenting in autism spectrum disorder?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  8. Article
  9. Article
  10. Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andrea De GiacomoSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-3454-1679
Silvia MedicamentoSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Chiara PedaciSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Donatella GiambersioSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Orazio Valerio GiannicoDepartment of Prevention, Local Health Authority of Taranto, 74121 Taranto, Italy.
Maria Giuseppina PetruzzelliSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-1734-788X
Marta SimoneSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-4381-4613
Massimo CorsaliniSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-0521-1363
Lucia MarzulliSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-7448-1017
Emilia MateraSchool of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-7541-0616
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is characterized by deficits in social skills and specific behaviors and interests. Among other environmental factors, iron may play a role in the development of ASD. The aim of this study is to compare the iron status of children with ASD with that of children affected by neurodevelopmental disorders other than ASD (OND). A total of 167 patients were enrolled, including 93 children with ASD and 74 children with OND. In the two groups, we determined ferritin, iron, transferrin, hemoglobin, HCT, and MCV in the serum. We found a significant difference in serum ferritin and MCV levels between the two groups (p < 0.05), with lower ferritin and higher MCV values in the ASD group. There was no significant association with the other variables. Our results may support the hypothesis of altered iron status in ASD, justifying more frequent examinations of blood iron parameters in these children.

Indexed as

Autism Spectrum DisorderNeurodevelopmental DisordersChildFerritinsHumansIronPreliminary DataFerritinsIronASDautismferritiniron statusMCV

Identifiers

PMID35409689
PMCPMC8997833
OpenAlexW4221077780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.