ReviewInternational journal of environmental research and public health2022
Central and Peripheral Fatigue in Physical Exercise Explained: A Narrative Review.
Review in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
126 citing papers in PubMed, 8 syntheses or guidelines pooled it, 204 citations in OpenAlex.
- Fatigue-induced changes in static and dynamic balance control in athletes with chronic ankle instability: a systematic review.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Effects of brain endurance training on physical and cognitive performance in athletes and physically active individuals: a systematic review.Frontiers in psychology · 2026Pooled it
- Changes in Physical Performance Following Operational Military Training: A Meta-Analysis.Sports medicine - open · 2025Pooled it
- Padel, pickleball and wellbeing: a systematic review.Frontiers in psychology · 2025Pooled it
- Effects of olympic combat sports on physical fitness in non-athlete students: a systematic review with meta-analysis.Frontiers in physiology · 2025Pooled it
- Effects of different peripheral fatigue protocol on lower limb biomechanical changes during landing and its impact on the risk of anterior cruciate ligament injury: a systematic review.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Coenzyme Q10 Supplementation in Athletes: A Systematic Review.Nutrients · 2023Pooled it
- Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2023Pooled it
- Effects of dietary nitrate supplementation on peak oxygen uptake following 10 days of Ramadan fasting in healthy adults.Experimental physiology · 2026Trial
- Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes.Journal of sports science & medicine · 2026Trial
- Trial
- Effects of a Psycho-Behavioural Intervention on Cancer-Related Fatigue Among Patients With Colorectal Cancer: A Pilot Randomised Controlled Trial.Psycho-oncology · 2026Trial
- The effect of regular exercise on general and mental fatigue and motivation during pregnancy: a randomized controlled trial.BMC pregnancy and childbirth · 2026Trial
- Effectiveness of a soccer injury prevention program based on creatine supplementation and internal load monitoring: a randomized controlled pilot study.Journal of the International Society of Sports Nutrition · 2025Trial
- The Effects of Virtual Reality-Based Task-Oriented Movement on Upper Extremity Function in Healthy Individuals: A Crossover Study.Medicina (Kaunas, Lithuania) · 2025Trial
- Trial
- Trial
- Trial
- Effects of β-Alanine Supplementation on Subjects Performing High-Intensity Functional Training.Nutrients · 2024Trial
- Trial
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of the origin and implications of fatigue in exercise has been widely investigated, but not completely understood given the complex multifactorial mechanisms involved. Then, it is essential to understand the fatigue mechanism to help trainers and physicians to prescribe an adequate training load. The present narrative review aims to analyze the multifactorial factors of fatigue in physical exercise. To reach this aim, a consensus and critical review were performed using both primary sources, such as scientific articles, and secondary ones, such as bibliographic indexes, web pages, and databases. The main search engines were PubMed, SciELO, and Google Scholar. Central and peripheral fatigue are two unison constructs part of the Integrative Governor theory, in which both psychological and physiological drives and requirements are underpinned by homeostatic principles. The relative activity of each one is regulated by dynamic negative feedback activity, as the fundamental general operational controller. Fatigue is conditioned by factors such as gender, affecting men and women differently. Sleep deprivation or psychological disturbances caused, for example, by stress, can affect neural activation patterns, realigning them and slowing down simple mental operations in the context of fatigue. Then, fatigue can have different origins not only related with physiological factors. Therefore, all these prisms must be considered for future approaches from sport and clinical perspectives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.