ArticleProceedings of the National Academy of Sciences of the United States of America1986
Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 172 citations in OpenAlex.
- MYB - A regulatory factor in hematopoiesis.Gene · 2018Review
- MoMyb1 is required for asexual development and tissue-specific infection in the rice blast fungus Magnaporthe oryzae.BMC microbiology · 2015Article
- Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults.BMC genomics · 2004Article
- Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells.Molecular pathology : MP · 2002Article
- Three novel MYB proteins with one DNA binding repeat mediate sugar and hormone regulation of alpha-amylase gene expression.The Plant cell · 2002Article
- Review
- The role of c-Myb in the up-regulation of methionine adenosyltransferase 2A expression in activated Jurkat cells.The Biochemical journal · 2001Article
- MYB-related transcription factor NtMYB2 induced by wounding and elicitors is a regulator of the tobacco retrotransposon Tto1 and defense-related genes.The Plant cell · 2000Article
- Article
- Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis.Molecular and cellular biology · 2000Article
- Target site search and effective inhibition of leukaemic cell growth by a covalently closed multiple anti-sense oligonucleotide to c-myb.The Biochemical journal · 2000Article
- A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression.Genes & development · 1998Article
- Drosophila myb is required for the G2/M transition and maintenance of diploidy.Genes & development · 1998Article
- DNA tetraplex formation in the control region of c-myc.Nucleic acids research · 1998Article
- The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1.Molecular and cellular biology · 1998Article
- Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- A Myb-related transcription factor is involved in the phytochrome regulation of an Arabidopsis Lhcb gene.The Plant cell · 1997Article
- A cdc5+ homolog of a higher plant, Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo.British journal of cancer · 1996Article
- Identification of an inducible regulator of c-myb expression during T-cell activation.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have isolated cDNA clones of the human c-myb mRNA that contain approximately 3.4 kilobases of the approximately 3.8-kilobase mRNA sequence. Nucleotide sequence analysis shows that the c-myb mRNA contains an open reading frame of 1920 nucleotides, which could encode a 72-kDa protein. The cDNA nucleotide sequence and the predicted amino acid sequence of the c-myb protein are highly homologous to the corresponding chicken and mouse proteins. In particular, a region toward the NH2 terminus of the protein containing a 3-fold tandem repeat of 51 residues is evolutionarily conserved and is the only region of homology with the Drosophila c-myb protein. This region may represent a functionally important structure, most likely the DNA-binding domain. cDNA clones have been used to isolate genomic clones and to define a preliminary intron/exon organization of the c-myb gene. Identification of 5' and 3' coding and noncoding exons indicates that the human c-myb locus spans a 40-kilobase region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.