Evidence map›Paper›PMID 35409369›Full record

ReviewInternational journal of molecular sciences2022

Small Prokaryotic DNA-Binding Proteins Protect Genome Integrity throughout the Life Cycle.

Katja Molan, Darja Žgur Bertok

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Comparative Proteomic Profiling of ClinicalJournal of extracellular biology · 2026
    Article
  2. Review
  3. Nucleoid-associated proteins: molecular mechanisms in microbial adaptation.World journal of microbiology & biotechnology · 2025
    Review
  4. Review
  5. The Dps Protein ProtectsInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. ProkDBP: Toward more precise identification of prokaryotic DNA binding proteins.Protein science : a publication of the Protein Society · 2024
    Article
  8. Article
  9. Article
  10. IHF and Fis asInternational journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Small Prokaryotic Proteins Interacting with Nucleic Acids.International journal of molecular sciences · 2022
    Article
  15. Molecular Link between DNA Damage Response and Microtubule Dynamics.International journal of molecular sciences · 2022
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katja MolanDepartment of Microbiology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0001-7883-9410
Darja Žgur BertokDepartment of Biology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.

Funding

Slovene research agency P1-0198
6 · The paper itself

Abstract

Genomes of all organisms are persistently threatened by endogenous and exogenous assaults. Bacterial mechanisms of genome maintenance must provide protection throughout the physiologically distinct phases of the life cycle. Spore-forming bacteria must also maintain genome integrity within the dormant endospore. The nucleoid-associated proteins (NAPs) influence nucleoid organization and may alter DNA topology to protect DNA or to alter gene expression patterns. NAPs are characteristically multifunctional; nevertheless, Dps, HU and CbpA are most strongly associated with DNA protection. Archaea display great variety in genome organization and many inhabit extreme environments. As of yet, only MC1, an archaeal NAP, has been shown to protect DNA against thermal denaturation and radiolysis. ssDNA are intermediates in vital cellular processes, such as DNA replication and recombination. Single-stranded binding proteins (SSBs) prevent the formation of secondary structures but also protect the hypersensitive ssDNA against chemical and nuclease degradation. Ionizing radiation upregulates SSBs in the extremophile

Indexed as

DeinococcusDNA-Binding ProteinsAnimalsBacterial ProteinsDNADNA ReplicationDNA, Single-StrandedLife Cycle StagesBacterial ProteinsDNADNA-Binding ProteinsDNA, Single-StrandedDNA protectionnucleoid-associated proteinssingle-stranded DNA-binding proteinssmall acid soluble proteins

Identifiers

PMID35409369
PMCPMC8999374

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.