Evidence map›Paper›PMID 35409297›Full record

ArticleInternational journal of molecular sciences2022

Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy.

Hongtao Liu, Chunlai Jiang, Yu Wu, Min Wu, Jiaxin Wu, Guanshu Zhao, Jie Sun, Xinyu Huang, Jiemin Li, Rui Sheng and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Hongtao LiuNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Chunlai JiangNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Yu WuDépartement Médicaments et Technologies pour la Santé (DMTS), CEA, INRAE, Université Paris-Saclay, SIMoS, 91191 Gif-sur-Yvette, France.ORCID 0000-0002-8250-7571
Min WuNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Jiaxin WuNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Guanshu ZhaoNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Jie SunNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Xinyu HuangNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Jiemin LiNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Rui ShengNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Julien BarbierDépartement Médicaments et Technologies pour la Santé (DMTS), CEA, INRAE, Université Paris-Saclay, SIMoS, 91191 Gif-sur-Yvette, France.ORCID 0000-0003-2187-4973
Jean-Christophe CintratDépartement Médicaments et Technologies pour la Santé (DMTS), CEA, INRAE, Université Paris-Saclay, SCBM, 91191 Gif-sur-Yvette, France.ORCID 0000-0001-5758-8077
Daniel GilletDépartement Médicaments et Technologies pour la Santé (DMTS), CEA, INRAE, Université Paris-Saclay, SIMoS, 91191 Gif-sur-Yvette, France.ORCID 0000-0003-0477-3599
Weiheng SuNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.ORCID 0000-0002-9577-7423
Jilin University · CNCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FR

Funding

Agence Nationale de la Recherche ANR-10-LABX-0033Agence Nationale de la Recherche ANR-11-IDEX-0003-02Agence Nationale de la Recherche ANR-18-CE18-0016-01National Natural Science Foundation of China 31770184National Natural Science Foundation of China 32070932National Natural Science Foundation of China 32170944Science and Technology Plan Project of The Inner Mongolia Autonomous Region, China 2020GG0233
6 · The paper itself

Abstract

Influenza virus is an acute and highly contagious respiratory pathogen that causes great concern to public health and for which there is a need for extensive drug discovery. The small chemical compound ABMA and its analog DABMA, containing an adamantane or a dimethyl-adamantane group, respectively, have been demonstrated to inhibit multiple toxins (diphtheria toxin,

Indexed as

AdamantaneInfluenza A Virus, H1N1 SubtypeAmantadineAnimalsAntiviral AgentsAutophagyEndosomesInfluenza A Virus, H3N2 SubtypeMiceMolecular Docking Simulationp-Dimethylaminoazobenzene4-dimethylaminoazobenzene-4'-N-maleimideAdamantaneAmantadineAntiviral Agentsp-DimethylaminoazobenzeneABMAautophagybroad-spectrum antiviralsDABMAinfluenza virus

Identifiers

PMID35409297
PMCPMC8999625
OpenAlexW4223484239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.