ArticleInternational journal of molecular sciences2022
Do Synovial Inflammation and Meniscal Degeneration Impact Clinical Outcomes of Patients Undergoing Arthroscopic Partial Meniscectomy? A Histological Study.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review.Cellular & molecular biology letters · 2024Pooled it
- Sagittal Tibial Tunnel Angle Is Associated with Meniscal Extrusion and Clinical Outcomes Following Transtibial Pull-Out Repair of Medial Meniscus Posterior Root Tears.Medicina (Kaunas, Lithuania) · 2026Article
- Pathological features of the lateral joint capsule and lateral retinaculum in lateral patellar compression syndrome: a retrospective case-control study.BMC musculoskeletal disorders · 2026Article
- All-Inside Versus Inside-Out Meniscus Repair: Gaps in the Long-Term Current Evidence.Bioengineering (Basel, Switzerland) · 2026Review
- Pathogenic Implications of the THY1/NF-κB Feedback Relationship in Osteoarthritis and Its Potential as a Therapeutic Target.Journal of inflammation research · 2026Article
- Amelioration of Post-traumatic Osteoarthritis by Iontophoretic Liposomal Strontium Ranelate Collaborated with Low-Intensity Pulsed Ultrasound in Rats.International journal of molecular sciences · 2025Article
- Potential sources of pain in symptomatic degenerative meniscal tear: A narrative review.Osteoarthritis and cartilage open · 2025Review
- Identification of Genes Linked to Meniscal Degeneration in Osteoarthritis: An In Silico Analysis.International journal of molecular sciences · 2025Article
- Account of synovial terminal nerve endings affects the clinical function of patients with chronic ankle instability : a retrospective cohort study.Bone & joint research · 2025Article
- Article
- Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data.Journal of inflammation research · 2025Article
- Knee temperature remains abnormal in patients successfully treated with anterior cruciate ligament reconstruction: An infrared thermography analysis.Journal of experimental orthopaedics · 2024Article
- Correlation of meniscus tear type with synovial inflammation and the therapeutic potential of docosapentaenoic acid.BMC musculoskeletal disorders · 2024Article
- Arthroscopic Linear Chain Fixation for the Treatment of Medial Meniscus Posterior Root Tear: A Case Study.Orthopaedic surgery · 2024Article
- Molecular Biology of Meniscal Healing: A Narrative Review.International journal of molecular sciences · 2024Review
- Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritis.Frontiers in endocrinology · 2024Article
- Using Single Peroneal Longus Tendon Graft for Segmental Meniscus Transplantation and Revision Anterior Cruciate Ligament Combined Anterolateral Reconstruction.Medicina (Kaunas, Lithuania) · 2023Article
- Biomechanics of Chondrocytes and Chondrons in Healthy Conditions and Osteoarthritis: A Review of the Mechanical Characterisations at the Microscale.Biomedicines · 2023Review
- Article
- Macroscopic Synovial Inflammation Correlates with Symptoms and Cartilage Lesions in Patients Undergoing Arthroscopic Partial Meniscectomy: A Clinical Study.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The menisci exert a prominent role in joint stabilization and in the distribution of mechanical loading. Meniscal damage is associated with increased risk of knee OA. The aim of this study was to characterize the synovial membrane and meniscal tissues in patients undergoing arthroscopic partial meniscectomy for meniscal tear and to evaluate association with clinical outcomes. A total of 109 patients were recruited. Demographic and clinical data were collected. Visual Analogic Scale (VAS) measuring pain and Knee injury and Osteoarthritis Outcome Score (KOOS) were recorded at baseline and at 2-years follow-up. Histological and immunohistochemical characterizations were performed on synovial membranes and meniscal tissues. More than half of the patients demonstrated synovial mononuclear cell infiltration and hyperplasia. Synovial fibrosis was present in most of the patients; marked vascularity and CD68 positivity were observed. Inflammation had an impact on both pain and knee symptoms. Patients with synovial inflammation had higher values of pre-operative VAS and inflammation. Higher pre-operative pain was observed in patients with meniscal MMP-13 production. In conclusion, multivariate analysis showed that synovial inflammation was associated with pre-operative total KOOS scores, knee symptoms, and pain. Moreover, meniscal MMP-13 expression was found to be associated with pre-operative pain in multivariate analysis. Thus, targeting inflammation of the synovial membrane and meniscus might reduce clinical symptoms and dysfunction at the time of surgery.
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Registered trials
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