Evidence map›Paper›PMID 35409250›Full record

ArticleInternational journal of molecular sciences2022

The Human Monocyte-A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation.

Sandra Lara, Srinivas Akula, Zhirong Fu, Anna-Karin Olsson, Sandra Kleinau, Lars Hellman

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Single-Cell Transcriptomics Reveals CCL3Journal of inflammation research · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Phenotypic and Functional Heterogeneity of Monocytes and Macrophages.International journal of molecular sciences · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sandra LaraDepartment of Cell and Molecular Biology, Uppsala University, The Biomedical Center, P.O. Box 596, SE-75124 Uppsala, Sweden.ORCID 0000-0002-1637-482X
Srinivas AkulaDepartment of Anatomy, Physiology, and Biochemistry, Swedish University of Agricultural Sciences, P.O. Box 7011, SE-75007 Uppsala, Sweden.ORCID 0000-0001-6628-1640
Zhirong FuDepartment of Cell and Molecular Biology, Uppsala University, The Biomedical Center, P.O. Box 596, SE-75124 Uppsala, Sweden.
Anna-Karin OlssonDepartment of Medical Biochemistry and Microbiology, BMC, P.O. Box 582, SE-75123 Uppsala, Sweden.
Sandra KleinauDepartment of Cell and Molecular Biology, Uppsala University, The Biomedical Center, P.O. Box 596, SE-75124 Uppsala, Sweden.
Lars HellmanDepartment of Cell and Molecular Biology, Uppsala University, The Biomedical Center, P.O. Box 596, SE-75124 Uppsala, Sweden.ORCID 0000-0003-1459-3815
Uppsala University · SESwedish University of Agricultural Sciences · SE

Funding

Knut and Alice Wallenberg Foundation KAW2017.0022
6 · The paper itself

Abstract

Monocytes were previously thought to be the precursors of all tissue macrophages but have recently been found to represent a unique population of cells, distinct from the majority of tissue macrophages. Monocytes and intestinal macrophages seem now to be the only monocyte/macrophage populations that originate primarily from adult bone marrow. To obtain a better view of the biological function of monocytes and how they differ from tissue macrophages, we have performed a quantitative analysis of its transcriptome in vivo and after in vitro stimulation with

Indexed as

LipopolysaccharidesMonocytesAdultCells, CulturedCytokinesEscherichia coliHumansInflammationInterleukin-6Interleukin-8CytokinesInterleukin-6Interleukin-8Lipopolysaccharidesantigen presentationchemokinecytokinecytokine stormG-CSFIL-6inflammatory responseLPSmacrophagemonocyte

Identifiers

PMID35409250
PMCPMC8999117
OpenAlexW4221053286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.