Evidence map›Paper›PMID 35409240›Full record

ArticleInternational journal of molecular sciences2022

Optogenetic Control of PIP2 Interactions Shaping ENaC Activity.

Tarek Mohamed Abd El-Aziz, Amanpreet Kaur, Mark S Shapiro, James D Stockand, Crystal R Archer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Optogenetic engineering for ion channel modulation.Current opinion in chemical biology · 2025
    Review
  3. Bidirectional Allosteric Coupling between PIPInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. PIPBiology · 2022
    Article
  6. Light-Controlled Modulation and Analysis of Neuronal Functions.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Tarek Mohamed Abd El-AzizDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228, USA.ORCID 0000-0002-3441-9673
Amanpreet KaurDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA.
Mark S ShapiroDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228, USA.
James D StockandDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228, USA.
Crystal R ArcherDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228, USA.ORCID 0000-0002-2377-643X
The University of Texas Health Science Center at San Antonio · USUniversity of Washington · US

Funding

Targeting specific interactions between A-kinase Anchoring Proteins (AKAPs) and ion channels with cell-permeant peptides as a novel mode of therapeutic intervention against pain disordersR01NS094461 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2015 to 2019
$2.0M
Mechanism and functional role of AKAP79/150 in M current control and excitabilityR01NS065138 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2009 to 2010
$788k
American Heart Association 857310NIH HHS 5R01KD113816-04 to JDSNINDS NIH HHS R01 NS065138NINDS NIH HHS R01 NS094461
6 · The paper itself

Abstract

The activity of the epithelial Na

Indexed as

Epithelial Sodium ChannelsPhosphatidylinositol 4,5-DiphosphateBinding SitesOptogeneticsPhosphatidylinositolsSodiumEpithelial Sodium ChannelsPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsSodiumCoroNa GreenCRY2ENaCoptogeneticphosphoinositidesPIP2sodium channel

Identifiers

PMID35409240
PMCPMC8998630
OpenAlexW4220784001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.